Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats

Figure 1 Effect of thioacetamide and celecoxib on liver fibrosis. A: Macroscopic analysis of liver tissue. Celecoxib improved pathological changes in the liver, as shown by hematoxylin-eosin and Sirius red (SR) staining (original magnification: × 100; scale bar = 400 μm); B: Ishak’s score based on histology and SR staining as well as alanine aminotransferase, aspartate aminotransferase, and hydroxyproline levels. The data are expressed as the mean ± SD (n = 15, ^aP < 0.05 vs TAA + celecoxib group; ^bP < 0.01 vs control group). TAA: Thioacetamide; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; HE: Hematoxylin-eosin staining.