Primary sclerosing cholangitis associated colitis: Characterization of clinical, histologic features, and their associations with liver transplantation

Table 4 Select histologic and clinical features of Primary sclerosing cholangitis-Inflammatory bowel disease patients with and without orthotopic liver transplantation, n (%)

	PSC-IBD with OLT1	PSC-IBD no OLT1	P value (PSC-IBD with OLT vs PSC-IBD no OLT)
Distribution
Right colon only	1 (10)	9 (30)	0.1
Left colon only	1 (19)	0 (0)	0.3
Right and left colon	8 (80)	11(37)	0.2
Rectum	8 (80)	8 (44)	0.04a
Ileum	2 (33)	7 (58)	0.6
Dysplasia	3 (30)	1 (4.7)	0.08
Treatment
Ursodiol	2 (20)	9 (45)	0.2
Steroids	3 (30)	7 (33)	1
ASA	6 (60)	11 (52)	1
Anti-TNF	1 (10)	5 (24)	0.6
Immunomodulators	3 (30)	3 (14)	0.3
Colectomy	5 (50)	5 (22)	0.2
Severity of acute inflammation (average activity score)
Right colon	1.5	1.2	0.4
Left colon	1.7	0.86	0.04a
Rectum	1.3	0.6	0.04b
Ileum	0.3	0.6	0.3
IBD duration (yr) (mean ± SD)	13.6 ± 12	8.5 ± 8.8	0.3

¹In all available patients and biopsied sites.

^aUni and multivariate analysis (P < 0.05).

^bUni and multivariate analysis (P < 0.05). SD: Standard deviation; ASA: 5-aminosalicylic acid; Anti-TNF: Anti-tumor necrosis factor; IBD: Inflammatory bowel disease; PSC: Primary sclerosing cholangitis; OLT: Orthotopic liver transplantation.