Can contrast enhanced ultrasound differentiate intrahepatic cholangiocarcinoma from hepatocellular carcinoma?

Figure 5 A 69-year-old female patient with an LR-M lesion. A: A hypoechoic nodule measuring 3.2 cm in diameter (arrow) was observed by conventional grayscale ultrasound in the left lobe of the liver; B: Contrast-enhanced ultrasound illustrated homogeneous hyperenhancement (arrow) in the arterial phase; C: Early washout was demonstrated (arrow) at 60 s after SonoVue injection; D: No marked washout (arrow) was observed by 120 s; E: This lesion was classified as LR-M, and moderately differentiated intrahepatic cholangiocarcinoma was confirmed by histopathology (hematoxylin and eosin staining, × 200).