Can contrast enhanced ultrasound differentiate intrahepatic cholangiocarcinoma from hepatocellular carcinoma?

Figure 4 Contrast-enhanced ultrasound examination of a 68-year-old male patient with chronic hepatitis B infection. A: Conventional grayscale ultrasound demonstrated a mixed echo nodule (arrow) measuring 3.0 cm in diameter in the left lobe of the liver; B: Contrast-enhanced ultrasound illustrated rim arterial phase hyperenhancement (arrow) in the arterial phase; C: Early washout of the contrast agent within 60 s was observed (arrow); D: Late-phase imaging demonstrated marked contrast washout (arrow) within 120 s. The lesion was classified as LR-M due to the aforementioned features; E: The nodule was revealed to be poorly differentiated hepatocellular carcinoma by histopathology (hematoxylin and eosin staining, × 400).