Can contrast enhanced ultrasound differentiate intrahepatic cholangiocarcinoma from hepatocellular carcinoma?

Figure 3 A 46-year-old female patient with an LR-M lesion. A: A hypoechoic nodule (arrow) measuring 4.7 cm in diameter was identified in the left lobe of the liver by conventional grayscale ultrasound; B: Peripheral rim-like arterial phase hyperenhancement (arrow) in the arterial phase was demonstrated by contrast-enhanced ultrasound; C: Early washout (arrow) was observed in the portal phase; D: No marked washout (arrow) was displayed until 155 s after SonoVue injection; E: Poorly differentiated ICC was confirmed by histopathology (hematoxylin and eosin staining, × 200).