Can contrast enhanced ultrasound differentiate intrahepatic cholangiocarcinoma from hepatocellular carcinoma?

Figure 2 A 54-year-old female patient with a lesion categorized as LR-M. A: Conventional grayscale ultrasound detected a hypoechoic nodule (arrow) 3.6 cm in diameter in the right lobe of the liver; B: Rim arterial phase hyperenhancement (APEH) (arrow) in the arterial phase was demonstrated by contrast-enhanced ultrasound; C and D: No washout (arrow) was observed in the early portal phase (by 60 s), and no marked washout (arrow) was observed by 126 s after SonoVue injection. This lesion was designated as LR-M because of rim APEH in the arterial phase; E: Poorly differentiated intrahepatic cholangiocarcinoma was confirmed by histopathology (hematoxylin and eosin staining, × 200).