Transarterial chemoembolization with hepatic arterial infusion chemotherapy plus S-1 for hepatocellular carcinoma

Table 4 Univariable and multivariable Cox regression analyses for overall survival

Factor	Univariable analysis		Multivariable analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age in yr	1.00 (0.98-1.02)	0.911	-	-
Sex as female/male	0.83 (0.45-1.53)	0.559	-	-
Tumor size in cm	1.01 (0.96-1.05)	0.722	-	-
Number of tumors
1	-	< 0.0011	-	0.0122
≥ 2	0.18 (0.08-0.41)	< 0.0011	0.27 (0.11-0.68)	0.0052
Infiltrative	0.33 (0.15-0.71)	0.0042	0.47 (0.21-1.05)	0.067
Portal vein invasion
No invasion	-	0.648	-	-
Stage I-II	0.83 (0.46-1.50)	0.533	-	-
Stage III-IV	1.02 (0.58-1.78)	0.946	-	-
Extrahepatic metastasis	1.37 (0.88-2.14)	0.168	-	-
Child-Pugh stage, A/B	1.39 (0.74-2.62)	0.305	-	-
Performance status, 0/1	1.14 (0.74-1.76)	0.560	-	-
AFP in ng/mL	1.00 (1.00-1.00)	0.0162	1.00 (1.00-1.00)	0.192
Albumin in g/L	0.97 (0.92-1.02)	0.188	-	-
Total bilirubin in mg/mL	1.03 (1.00-1.05)	0.0192	1.01 (0.98-1.03)	0.505
GGT	1.00 (1.00-1.00)	< 0.0011	1.00 (1.00-1.00)	0.060
ALT	1.00 (1.00-1.01)	0.625	-	-
AST	1.00 (1.00-1.01)	0.127	-	-
Target treatment, yes/no	0.65 (0.35-1.19)	0.163	-	-
S-1 treatment, yes/no	1.00 (0.67-1.50)	0.985	-	-
Tumor response
CR	-	< 0.0011	-	< 0.0011
PR	0.02 (0.00-0.07)	< 0.0011	0.02 (0.00-0.09)	< 0.0011
SD	0.11 (0.06-0.21)	< 0.0011	0.11 (0.06-0.22)	< 0.0011
PD	0.20 (0.12-0.32)	< 0.0011	0.20 (0.12-0.32)	< 0.0011

¹The P value is < 0.001.

²The P value is < 0.05. CI: Confidence interval; AFP: Alpha-fetoprotein; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; CR: Complete response; GGT: Gamma-glutamyl transferase; HR: Hazard ratio; PD: Progressive disease; PR: Partial response; SD: Stable disease.