Transarterial chemoembolization with hepatic arterial infusion chemotherapy plus S-1 for hepatocellular carcinoma

Table 3 Univariable and multivariable Cox regression analyses for progression-free survival

Factor	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age in yr	0.99 (0.97-1.01)	0.215	-	-
Sex as female/male	0.73 (0.42-1.29)	0.283	-	-
Tumor size in cm	1.04 (1.00-1.09)	0.0401	1.04 (0.99-1.08)	0.098
Number of tumors
1	-	0.0041	-	0.0281
≥ 2	0.28 (0.12-0.62)	0.0021	0.36 (0.15-0.85)	0.0191
Infiltrative	0.48 (0.23-1.01)	0.052	0.60 (0.28-1.30)	0.193
Portal vein invasion
No invasion	-	0.566	-	-
Stage I-II	0.75 (0.43-1.30)	0.303	-	-
Stage III-IV	0.89 (0.54-1.47)	0.645	-	-
Extrahepatic metastasis	1.25 (0.83-1.89)	0.285	-	-
Child-Pugh stage, A/B	1.13 (0.62-2.06)	0.702	-	-
Performance status, 0/1	1.10 (0.73-1.66)	0.651	-	-
AFP in ng/mL	1.00 (1.00-1.00)	0.050	1.00 (1.00-1.00)	0.212
Albumin in g/L	0.97 (0.93-1.02)	0.246	-	-
Total bilirubin in mg/mL	1.02 (1.00-1.04)	0.088	1.00 (1.00-1.02)	0.960
GGT	1.00 (1.00-1.00)	0.0031	1.00 (1.00-1.00)	0.0321
ALT	1.00 (1.00-1.01)	0.114	-	-
AST	1.00 (1.00-1.01)	0.0081	1.00 (1.00-1.01)	0.149
Targeted treatment, yes/no	0.86 (0.50-1.49)	0.589	-	-
S-1 treatment, yes/no	0.90 (0.61-1.32)	0.585	-	-

¹The P value is < 0.05. CI: Confidence interval; AFP: Alpha-fetoprotein; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transferase; HR: Hazard ratio.