Serum ceruloplasmin can predict liver fibrosis in hepatitis B virus-infected patients

Table 5 Comparisons of ceruloplasmin hepatitis B virus with other predictive models for assessing F ≥ 2 (n = 275)

Model	AUC (95%CI)	Youden index	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	P value
CPHBV	0.839 (0.792-0.886)	0.512	80.1	71.1	76.2	72.4
APRI	0.704 (0.639-0.768)	0.355	75.9	59.6	68.5	66.1	< 0.001
FIB-4	0.678 (0.612-0.745)	0.330	71.9	61.4	68.8	64.2	< 0.001
GPR	0.704 (0.640-0.768)	0.350	74.5	60.5	70.1	66.7	< 0.001
Forn’s index	0.687 (0.622-0.753)	0.359	63.1	72.8	74.2	61.5	< 0.001
S-index	0.722 (0.659-0.784)	0.357	78.7	57.0	69.9	69.7	0.0034

AUC: Area under the receiver operating characteristic curve; NPV: Negative predictive value; PPV: Positive predictive value; CPHBV: Ceruloplasmin hepatitis B virus; APRI: Aspartate aminotransferase-to-platelet ratio index; FIB-4: Fibrosis-4; GPR: Gamma-glutamyl transpeptidase-to-platelet ratio.