Serum ceruloplasmin can predict liver fibrosis in hepatitis B virus-infected patients

Table 3 Clinical parameters associated with significant fibrosis in the training group (138 patients)

		No significant fibrosis (n = 64)	Significant fibrosis (n = 74)	P value
Age (yr)		39.88 ± 9.68	39.61 ± 9.37	0.260
Gender	Male	47 (73.4%)	54 (73.0%)	0.951
	Female	17 (26.6%)	20 (27.0%)
CP (mg/L)		231.22 ± 35.26	196.73 ± 42.27	< 0.0001
Total bilirubin (μmol/L)		13.11 ± 6.97	13.48 ± 6.05	0.747
Albumin (g/L)		44.27 ± 3.29	41.79 ± 3.75	<0.0001
Globulin (g/L)		27.15 ± 5.15	31.35 ± 5.03	0.363
ALT (IU/L)		29.25 ± 10.32	30.00 ± 9.17	0.652
AST (IU/L)		25.77 ± 7.21	27.53 ± 7.11	0.152
GGT (IU/L)		23.69 ± 13.96	33.90 ± 29.78	0.017
TCHO (mmol/L)		4.82 ± 0.83	4.44 ± 0.62	0.004
TG (mmol/L)		1.31 ± 0.74	1.21 ± 0.85	0.474
CHE (IU/mL)		9254.48 ± 2583.76	7710.21 ± 1903.41	< 0.0001
WBC (109/L)		5.78 ± 1.36	5.71 ± 1.59	0.766
PLT (109/L)		212.63 ± 50.24	177.49 ± 47.94	< 0.0001
HBsAg (Log IU/mL)		4.40 ± 0.78	3.45 ± 0.96	< 0.0001
HBV-DNA (Log IU/mL)		5.17 ± 2.33	5.00 ± 1.70	0.614
PT (s)		11.71 ± 2.81	12.33 ± 2.31	0.161
INR		0.96 ± 0.23	1.02 ± 0.19	0.103

CP: Ceruloplasmin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma glutamyl transpeptidase; TCHO: Total cholesterol; TG: Triglyceride; CHE: Cholinesterase; WBC: White blood cell count; PLT: Platelet count; HBV: Hepatitis B virus; PT: Prothrombin time; INR: International normalized ratio.