Serum ceruloplasmin can predict liver fibrosis in hepatitis B virus-infected patients

Table 2 Accuracy of serum ceruloplasmin in diagnosing F ≥ 2, F ≥ 3, and F = 4 as measured by area under the receiver operating characteristic curve (n = 138)

Steatosis degree	AUC (95%CI)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Cut-off point
F ≥ 2	0.774 (0.696-0.851)	81.3	64.9	66.7	80	≤ 203.5
F ≥ 3	0.812 (0.732-0.892)	82.8	65.9	83.7	64.4	≤ 190.5
F = 4	0.853 (0.781-0.925)	89.3	65.4	91.7	58.6	≤ 182.5

CP: Ceruloplasmin; AUC: Area under the receiver operating characteristic curve; NPV: Negative predictive value; PPV: Positive predictive value.