Can contrast enhanced ultrasound differentiate intrahepatic cholangiocarcinoma from hepatocellular carcinoma?

Table 4 The receiver operating characteristic curve analysis for diagnostic performance of contrast-enhanced ultrasound liver imaging reporting and data system LR-M characteristics in differentiation intrahepatic cholangiocarcinoma and LR-M hepatocellular carcinoma

Criterion	AUC	95%CI	Sensitivity(%)	95%CI	Specificity (%)	95%CI	+LR	95%CI	-LR	95%CI
Rim APHE	0.7	0.63-0.76	70.4	58.4-80.7	68.8	60.9-75.9	2.3	1.9-2.7	0.4	0.3-0.7
Early washout	0.56	0.49-0.62	57.1	50.3-63.8	54.6	23.4-83.3	1.3	0.7-2.2	0.8	0.4-1.5
Marked washout	0.65	0.59-0.72	69.7	51.3-84.4	61	53.8-67.9	1.8	1.4-2.3	0.5	0.3-0.9
Rim APHE + elevated CA 19-9 + normal AFP	0.82	0.76-0.87	100	86.8-100	63.9	56.8-70.5	2.8	2.5-3.1	-	-

ROC: Receiver operator characteristic curve; AUC: Area under curve; ICC: Intrahepatic cholangiocarcinoma; HCC: Hepatocellular carcinoma; CA 19-9: Carbohydrate antigen 19-9; AFP: Alpha fetoprotein; CEUS: Contrast enhanced ultrasound; LI-RADS: Liver imaging reporting and data system; APHE: Arterial phase hyperenhancement; 95% CI: 95% confidence interval; +LR: Positive likelihood ratio; -LR: Negative likelihood ratio.