Can contrast enhanced ultrasound differentiate intrahepatic cholangiocarcinoma from hepatocellular carcinoma?

Table 3 Comparison of the LR-M features between intrahepatic cholangiocarcinoma and LR-M hepatocellular carcinoma

χ2 test	Rim APHE + late and mild washout		APHE + early and mild washout		APHE + late and marked washout		Rim APHE + early and marked washout		Rim APHE + early and mild washout		Rim APHE + late and marked washout		APHE + early and marked washout
	ICC	LR-M HCC	ICC	LR-M HCC	ICC	LR-M HCC	ICC	LR-M HCC	ICC	LR-M HCC	ICC	LR-M HCC	ICC	LR-M HCC
Positive	4	5	42	101	0	0	14	3	30	13	2	0	7	7
Negative	95	124	57	28	99	129	8	126	9	116	97	129	92	122
Proportion(%)	4	3.9	42.4	78.3	0	0	14.1	2.3	30.3	10.1	2	0	7.1	5.4
P value	> 0.05		< 0.0001		-		0.0018		0.0002		> 0.05		> 0.05
95%CI	-5.6%-6.6%		22.8%-47.8%		-		4.3%-20.4%		9.2%-31.3%		-1.3%-7.1%		-5.2%-9.4%

ICC: Intrahepatic cholangiocarcinoma; HCC: Hepatocellular carcinoma; CEUS: Contrast enhanced ultrasound; LI-RADS: Liver imaging reporting and data system. APHE: Arterial phase hyperenhancement; 95% CI: 95% confidence interval.