Copyright
©The Author(s) 2020.
World J Gastroenterol. Jul 21, 2020; 26(27): 3851-3864
Published online Jul 21, 2020. doi: 10.3748/wjg.v26.i27.3851
Published online Jul 21, 2020. doi: 10.3748/wjg.v26.i27.3851
Table 3 Relevant mechanisms of hypertension after liver transplantation induced by common immunosuppressive agents[42]
| Category | Drug | Mechanism | |
| CNI | TAC, CsA | Increasing vascular tension: reducing nitric oxide (NO) and increasing endothelin level | |
| Increasing sympathetic excitability | |||
| Activating the angiotensin-aldosterone system: elevated blood pressure, water, and sodium retention | |||
| Activating sodium-chloride synergistic transport receptors in distal tubules: increased sodium reabsorption and excessive capacity | |||
| Nephrotoxicity: AKI induced by vasoconstriction Chronic ischemia, glomerulosclerosis, interstitial fibrosis, and tubular atrophy | |||
| Glucocorticoid | Methylprednisolone | Increasing sympathetic excitability | |
| Increasing vascular tension | |||
| Increasing activity of mineralocorticoids | |||
- Citation: Shen T, Zhuang L, Sun XD, Qi XS, Wang ZH, Li RD, Chang WX, Yang JY, Yang Y, Zheng SS, Xu X. Expert consensus on management of metabolic disease in Chinese liver transplant recipients. World J Gastroenterol 2020; 26(27): 3851-3864
- URL: https://www.wjgnet.com/1007-9327/full/v26/i27/3851.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i27.3851