Combining protein arginine methyltransferase inhibitor and anti-programmed death-ligand-1 inhibits pancreatic cancer progression

Figure 1 Programmed death-ligand-1 expression in pancreatic ductal adenocarcinoma in vitro and in vivo. A: Panc02 cells were subcutaneously transplanted into C57BL/6 mice to establish pancreatic tumors (orange arrow); B: Programmed death-ligand-1 expression levels in cultured pancreatic cancer cells (in vitro) and tumors (in vivo). The mean fluorescence intensity was used to quantify protein expression levels, and the values were statistically analyzed by a two-sided t-test; the results are presented at the bottom. Data represent the mean ± SE (n = 3). ^aP < 0.05 vs in vitro condition. PD-L1: Programmed death-ligand-1; MFI: Mean fluorescence intensity.