Copyright
©The Author(s) 2020.
World J Gastroenterol. Jul 14, 2020; 26(26): 3814-3833
Published online Jul 14, 2020. doi: 10.3748/wjg.v26.i26.3814
Published online Jul 14, 2020. doi: 10.3748/wjg.v26.i26.3814
Table 2 Correlations between immunohistochemical expression of Notch, Numb, Itch, and Siah-1 and clinicopathological parameters
| Parameters | n | Notch | Numb | Itch | Siah-1 | ||||
| Negative (%) | Positive (%) | Negative (%) | Positive (%) | Negative (%) | Positive (%) | Negative (%) | Positive (%) | ||
| Age | 18 | 32 | 30 | 20 | 30 | 20 | 29 | 21 | |
| 64 ± 12.35 ≥ | 24 | 8 (44.3) | 16 (66.7) | 13 (54.1) | 11 (45.9) | 14 (58.3) | 10 (41.7) | 16 (66.7) | 8 (33.3) |
| 64 ± 12.35 < | 26 | 10 (38.5) | 16 (61.5) | 17 (65.3) | 9 (34.7) | 16 (61.5) | 10 (38.5) | 13 (50) | 13 (50) |
| Gender | |||||||||
| Female | 17 | 6 (35.3) | 11 (66.7) | 10 (58.8) | 7 (41.2) | 10 (58.8) | 7 (42.2) | 7 (41.2) | 10 (58.8) |
| Male | 33 | 12 (36.4) | 21 (63.6) | 20 (60.6) | 13 (39.4) | 20 (60.6) | 13 (39.4) | 22 (66.7) | 11 (33.3) |
| Localization | |||||||||
| Caecum | 8 | 3 (37.59) | 5 (62.5) | 6 (75) | 2 (25) | 5 (62.5) | 3 (37.5) | 4 (50) | 4 (50) |
| Colon | 16 | 5 (31.3) | 11 (68.7) | 9 (56.3) | 7 (43.7) | 8 (50) | 8 (50) | 10 (62.5) | 6 (37.5) |
| Sigmoid | 10 | 4 (40) | 6 (60) | 7 (70) | 3 (30) | 7 (70) | 3 (30) | 5 (50) | 5 (50) |
| Rectum | 16 | 6 (37.5) | 10 (62.5) | 8 (50) | 8 (50) | 10 (62.5) | 6 (37.5) | 10(50) | 6 (50) |
| Differentiationa | |||||||||
| WD | 18 | 16 (88.8) | 2 (11.2) | 3 (16.6) | 15 (83.4) | 5 (27.8) | 13 (72.8) | 8 (44.5) | 10 (55.5) |
| MD | 15 | 1 (6.6) | 14 (93.4) | 12 (80) | 3 (20) | 10 (66.7) | 5 (33.3) | 10 (66.6) | 5 (33.4) |
| PD | 17 | 1 (5.8) | 16 (94.2) | 15 (88.2) | 2 (11.8) | 15 (88.2) | 2 (11.8) | 11 (64.8) | 6 (35.2) |
| Invasion | |||||||||
| T1 | 7 | 6 (85.7) | 1 (14.3) | 4 (57.1) | 3 (42.9) | 2 (28.5) | 5 (71.5) | 3 (48.3) | 4 (51.7) |
| T2 | 10 | 6 (60) | 4 (40) | 7 (70) | 3 (30) | 7 (70) | 3 (30) | 6 (60) | 4 (40) |
| T3 | 23 | 4 (17.4) | 19 (82.6) | 12 (52.1) | 11 (47.9) | 15 (65.2) | 8 (34.8) | 14 (60.9) | 9 (39.1) |
| T4 | 10 | 2 (20) | 8 (80) | 7 (70) | 3 (30) | 6 (60) | 4 (40) | 6 (60) | 4 (40) |
| LNMa | |||||||||
| Absent | 17 | 1 (5.3) | 17 (94.7) | 5 (29.4) | 12 (70.6) | 7 (41.1) | 10 (58.9) | 4 (23.6) | 13 (76.4) |
| Present | 33 | 17 (61.39) | 21(38.7) | 25 (75.8) | 8 (24.2) | 23 (69.6) | 10 (30.4) | 25 (75.8) | 8 (24.2) |
| Lymphatic invasion | |||||||||
| Absent | 37 | 17 (45.9) | 20 (54.1) | 22 (59.4) | 15 (40.6) | 23 (62.1) | 14(37.9) | 25 (67.6) | 12 (32.4) |
| Present | 13 | 1 (7.6) | 12 (92.4) | 8 (61.5) | 5 (38.5) | 7 (53.8) | 6 (45.2) | 4 (30.8) | 9 (69.2) |
| Vascular invasion | |||||||||
| Absent | 42 | 16 (38.1) | 26 (61.9) | 25 (61.9) | 17(38.1) | 27 (64.3) | 15 (35.7) | 26 (61.9) | 16 (38.1) |
| Present | 8 | 2 (25) | 6 (75) | 5 (62.5) | 3 (37.5) | 3 (62.5) | 5 (37.5) | 3 (37.5) | 5 (62.5) |
| Perineural invasion | |||||||||
| Absent | 31 | 11 (35,4) | 20 (64.6) | 21 (67.7) | 10 (32.3) | 20 (64.5) | 11 (35.5) | 18 (58.1) | 13 (41.9) |
| Present | 19 | 7 (36.8) | 12 (63.2) | 9 (47.4) | 10 (52.6) | 10 (52.6) | 9 (47.4) | 11 (57.9) | 8 (42.1) |
| Stagea | |||||||||
| 1 + 2 | 24 | 13 (54.1) | 11 (45.9) | 8 (33.4) | 16 (66.6) | 10 (41.6) | 14 (58.4) | 10 (41.7) | 14 (58.3) |
| 3 + 4 | 26 | 5 (19.2) | 21 (80.8) | 22 (84.6) | 4 (15.4) | 20 (76.9) | 6 (23.1) | 19 (73.1) | 7 (26.9) |
| Distant metastasis | |||||||||
| Absent | 26 | 8 (30.7) | 18 (69.3) | 15 (57.6) | 11 (42.4) | 13 (50) | 13 (50) | 15 (57.7) | 11(42.3) |
| Present | 24 | 10 (41.6) | 14 (58.4) | 15 (62.5) | 9 (37.5) | 17 (70.8) | 7 (29.2) | 14 (58.4) | 10 (41.6) |
| Survival (mo)a | |||||||||
| 60.62 ± 26.68 ≥ | 26 | 2 (7.6) | 24 (92.4) | 20 (76.9) | 6 (23.1) | 22 (84.6) | 4 (15.4) | 19 (73.1) | 7 (26.9) |
| 60.62 ± 26.68 < | 24 | 16 (66.6) | 8 (33.4) | 10 (41.7) | 14 (58.3) | 8 (33.4) | 16 (66.6) | 10 (41.7) | 14 (58.3) |
- Citation: Gonulcu SC, Unal B, Bassorgun IC, Ozcan M, Coskun HS, Elpek GO. Expression of Notch pathway components (Numb, Itch, and Siah-1) in colorectal tumors: A clinicopathological study. World J Gastroenterol 2020; 26(26): 3814-3833
- URL: https://www.wjgnet.com/1007-9327/full/v26/i26/3814.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i26.3814