Copyright
©The Author(s) 2020.
World J Gastroenterol. Jul 14, 2020; 26(26): 3814-3833
Published online Jul 14, 2020. doi: 10.3748/wjg.v26.i26.3814
Published online Jul 14, 2020. doi: 10.3748/wjg.v26.i26.3814
Table 1 Distribution of immunohistochemical expression of Notch, Numb, Itch, and Siah-1 among the three groups, tissues adjacent to carcinoma, tissues adjacent to adenoma, and subtypes of adenomas
| Controls | Adenomas | Carcinomas | P value | Tissues adjacent to carcinomaa | Tissues adjacent to adenomaa | Subtypes of adenomasa | |||
| Tubular | Tubulovillous | Villous | |||||||
| Notch expression | |||||||||
| Negative (%) | 15 (75) | 12 (40) | 18 (36) | 0.02 | 25 (50) | 16 (53) | 4 (40) | 5 (50) | 3 (30) |
| Positive (%) | 5 (25) | 18 (60) | 32 (64) | 25 (50) | 14 (47) | 6 (60) | 5 (50) | 7 (70) | |
| Numb expression | |||||||||
| Negative (%) | 6 (30) | 21 (70) | 30 (60) | 0.008 | 26 (52) | 14 (47) | 6 (60) | 7 (70) | 8 (80) |
| Positive (%) | 14 (70) | 9 (30) | 20 (40) | 24 (48) | 16 (54) | 4 (40) | 3 (30) | 2 (20) | |
| Itch expression | |||||||||
| Negative (%) | 8 (40) | 24 (80) | 30 (60) | 0.01 | 27(54) | 19 (63) | 9 (90) | 7 (70) | 8 (80) |
| Positive (%) | 12 (60) | 6 (20) | 20 (40) | 23 (46) | 11 (37) | 1 (10) | 3 (30) | 2 (20) | |
| Siah-1 expression | |||||||||
| Negative (%) | 5 (25) | 19 (63.3) | 29 (58) | 0.024 | 31(62) | 21 (70) | 7 (70) | 5 (50) | 7 (70) |
| Positive (%) | 15 (75) | 11 (36.7) | 21 (42) | 19 (38) | 9 (30) | 3 (30) | 5 (50) | 3 (30) | |
- Citation: Gonulcu SC, Unal B, Bassorgun IC, Ozcan M, Coskun HS, Elpek GO. Expression of Notch pathway components (Numb, Itch, and Siah-1) in colorectal tumors: A clinicopathological study. World J Gastroenterol 2020; 26(26): 3814-3833
- URL: https://www.wjgnet.com/1007-9327/full/v26/i26/3814.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i26.3814