Monoacylglycerol lipase reprograms lipid precursors signaling in liver disease

Figure 1 Catabolic pathways regulating triglycerides levels in adipocytes. Adipose triglyceride lipase, hormone sensitive lipase, and monoacylglycerol lipase act on triglycerides in a series of subsequent reactions in order to generate glycerol and fatty acids. Comparative gene identification-58 binds to perilipin facilitating lipolysis, as a known activator of adipose triglyceride lipase. Intermediates of this catabolic pathway may also be re-esterified to phospholipids and triglycerides by the enzymes monoacyglycerol acyltransferases and diacylglycerol acyltransferase. ATGL: Adipose triglyceride lipase; HSL: Hormone sensitive lipase; MGL: Monoacylglycerol lipase; TGs: Triglycerides; FAs: Fatty acids; CGI-58: Comparative gene identification-58; MGAT: Monoacyglycerol acyltransferases; DGAT: Diacylglycerol acyltransferase.