Development of innovative tools for investigation of nutrient-gut interaction

doi:10.3748/wjg.v26.i25.3562

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 7, 2020; 26(25): 3562-3576
Published online Jul 7, 2020. doi: 10.3748/wjg.v26.i25.3562

Table 2 Enteroendocrine cell models

Species	Model	Origin	Hormones	Features
Mouse	STC-1	Duodenal secretin tumour cells	GLP-1, GLP-2, CCK, GIP, PYY,	Heterogeneous cell population; respond to glucose, amino acids, fatty acids and neural stimuli; poor expression of CaSR
	GLUTag	Colonic tumour	GLP-1, GLP-2, CCK	Subcloned homogenous cells; respond to glucose, bile acids, fatty acids, amino acids
Human	NCI-H716	Colorectal carcinoma	GLP-1, GLP-2	Heterogeneous cell population; poorly differentiated; respond to glucose, fatty acids, protein hydrolysates
	HuTu-80	Duodenal carcinoma	GLP-1, PYY, GIP, CCK	Respond to antioxidant compounds, sweet and bitter substances

CCK: Cholecystokinin; GLP-1: Glucagon-like peptide 1; GIP: Glucose-dependent insulinotropic polypeptide; PYY: Peptide YY; CaSR: Ca²⁺-sensing receptor.

Citation: Huang WK, Xie C, Young RL, Zhao JB, Ebendorff-Heidepriem H, Jones KL, Rayner CK, Wu TZ. Development of innovative tools for investigation of nutrient-gut interaction. World J Gastroenterol 2020; 26(25): 3562-3576
URL: https://www.wjgnet.com/1007-9327/full/v26/i25/3562.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i25.3562