Value of intravoxel incoherent motion in detecting and staging liver fibrosis: A meta-analysis

Table 2 Methodological and imaging protocol characteristics of included studies

Ref.	Reference standard	Scoring system	F0/F1/F2/F3/F4	Mean intervals	Double blindness	Scanner	FS	Trigger methods	b values	Scan time1
Yoon et al[30], 2019	S/B	METAVIR	13/6/19/18/50	6 (4-38) d	Yes	GE	1.5 T	FB	0, 15, 25.4, 42.9, 72.5, 122.5, 207, 350, 592, 1000	4.5
Fu et al[25], 2019	S/B	METAVIR	26/17/33/25/24	< 1 mo	Yes	GE	3.0 T	RT	0, 50, 100, 150, 200, 300, 500, 800, 1000, 1300, 1500, 1700, 2000	10
Zawada et al[34], 2019	B	Scheuer scale	7/17/10/2/2	NA	Unclear	GE	1.5 T	RT	0, 20, 50, 100, 200, 400, 600, 800, 1000	2.6
Sandrasegaran et al[32], 2018	B	METAVIR	4/8/2/9/26	< 3 mo	Unclear	Siemens	1.5 T	RT	0, 50, 100, 300, 600, 800	12-15
Seo et al[31], 2018	S/B/T	Batts-Ludwig	30/14/4/18/29	81.2 d	Yes	Philips	3.0 T	FB	0, 10, 25, 50, 75, 100, 200, 500, 800	4.25
Hu et al[29], 2017	B	METAVIR	6/19/13/8/10	6 d	Unclear	Siemens	3.0 T	NA	0, 25, 50, 75, 100, 150, 200, 500, 800	5
Chung et al[35], 2015	B/I	METAVIR	21/1/6/7/22	15.9 (2–43) d	Unclear	Siemens	1.5 T	RT	0, 30, 60, 100, 150, 200, 400, 600, 900	7
Wu et al[27], 2015	S	METAVIR	6/16/10/10/7	< 7 d	Unclear	Siemens	3.0 T	RT	0, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 200, 300, 400, 500, 1000	< 7
Ichikawa et al[26], 2015	S/B	METAVIR	72/13/14/19/64	< 3 mo	Unclear	GE	3.0 T	RT	0, 10, 20, 30, 40, 50, 80, 100, 200, 500, 1000	2-3
Parente et al[28], 2015	B	METAVIR	43/9/5/1/1	< 3 mo	Unclear	Philips	3.0 T	RT	0, 10, 20, 40, 80, 160, 200, 400, 800, 1000	3
Chen et al[24], 2014	B	METAVIR	25/4/9/11/1	< 1 mo	Unclear	GE	3.0 T	RT	0, 50, 100, 200, 400, 600, 800	NA
Yoon et al[33], 2014	S/B/T	METAVIR	11/7/7/9/21	NA	Unclear	Siemens	3.0 T	FB	0, 25, 50, 75, 100, 200, 500, 800	6.5

¹The unit of scan time is min. NA: Not available; S: Liver surgery; B: Percutaneous liver biopsy; T: Liver transplantation; I: Imaging findings; FS: Field strength; FB: Free breathing; RT: Respiratory triggered.