Pancreatic necrosis and severity are independent risk factors for pancreatic endocrine insufficiency after acute pancreatitis: A long-term follow-up study

Table 1 Baseline clinical characteristics of enrolled acute pancreatitis patients

	All patients (n = 361)	Normal glucose group (n = 211)	Dysglycemia group (n = 150)	P value
Age	48.63 ± 13.36	49.25 ± 13.83	47.75 ± 12.66	0.2921
Sex, n (%)
Male	201 (55.7)	117 (55.5)	84 (56)	0.9172
Female	160 (44.3)	94 (44.5)	66 (44)
BMI	23.36 ± 3.98	23.37 ± 4.039	23.36 ± 3.91	0.7711
APACHE II score	8.46 ± 3.80	8.18 ± 3.52	8.87 ± 4.14	0.5081
Etiology, n (%)
Biliary	166 (46)	103 (48.8)	63 (42)	0.4732
HTG	130 (36)	69 (32.7)	61 (40.7)
Alcoholic	52 (14.4)	31 (14.7)	21 (14)
Others	13 (3.6)	8 (3.8)	5 (3.3)
Severity of AP
Mild	47 (13.0)	41 (19.4)	6 (4.0)	0.0012
Moderate	199 (55.1)	115 (54.5)	84 (56.0)
Severe	115 (31.9)	55 (26.1)	60 (40.0)
Organ failure
Yes	137 (38.0)	53 (25.1)	84 (56.0)	0.0012
No	224 (62.0)	158 (74.9)	66 (44.0)
Pancreatic necrosis
Yes	152 (42.1)	34 (16.1)	118 (78.7)	0.0012
No	209 (57.9)	177 (83.9)	32 (21.3)
Debridement of necrosis (minimally invasive and/or ON)
Yes	95 (26.3)	25 (11.8)	70 (46.7)	0.0012
No	266 (73.7)	186 (88.2)	80 (53.3)
History of smoking
Yes	81 (22.4)	46 (21.8)	35 (23.3)	0.7312
No	280 (77.6)	165 (78.2)	115 (76.7)
History of drinking
Yes	81 (22.4)	68 (32.2)	13 (8.6)	0.7312
No	280 (77.6)	143 (67.8)	137 (91.4)
Time interval (mo)	24.04 ± 23.67	18.73 ± 19.10	31.53 ± 27.27	0.0011

¹t test, comparison between normal glucose group and dysglycemia group.

²χ² test, comparison between training group and validation group. BMI: Body mass index; APACHE II: Acute physiology and chronic health evaluation II; HTG: Hypertriglyceridemia; AP: Acute pancreatitis; ON: Operative necrosectomy.