Medications in type-2 diabetics and their association with liver fibrosis

Table 3 Assessment of associations between clinical factors and advanced fibrosis

Factor	Unadjusted		Adjusted1
	OR (95%CI)	P value	OR (95%CI)	P value
Hypertension	0.59 (0.46, 0.76)	< 0.001	0.52 (0.39, 0.68)	< 0.001
Hyperlipidemia	0.45 (0.35, 0.58)	< 0.001	0.42 (0.32, 0.54)	< 0.001
CKD	3.3 (2.1, 5.1)	< 0.001	2.6 (1.7, 4.2)	< 0.001
IBD	0.91 (0.47, 1.8)	0.79	0.94 (0.47, 1.9)	0.85
DVT	1.1 (0.67, 1.9)	0.64	0.99 (0.58, 1.7)	0.97
Oral Hypoglycemic medications	0.67 (0.52, 0.85)	0.001	0.69 (0.53, 0.89)	0.004
Metformin use	0.60 (0.47, 0.76)	< 0.001	0.64 (0.49, 0.82)	< 0.001
Glipizide use	0.86 (0.57, 1.3)	0.48	0.93 (0.60, 1.4)	0.75
Pioglitazone use	0.73 (0.49, 1.10)	0.13	0.71 (0.47, 1.08)	0.11
Sitagliptin/Januvia use	0.99 (0.68, 1.4)	0.95	0.95 (0.65, 1.4)	0.79
Insulin	0.96 (0.74, 1.3)	0.77	1.02 (0.77, 1.3)	0.91
Liraglutide use	0.26 (0.12, 0.55)	< 0.001	0.30 (0.14, 0.64)	0.002
Detemir/Levemir use	0.82 (0.48, 1.4)	0.49	0.94 (0.53, 1.7)	0.83
Lantus use	1.3 (0.95, 1.8)	0.10	1.3 (0.92, 1.8)	0.14
Humulin use	0.67 (0.38, 1.2)	0.18	0.75 (0.41, 1.4)	0.35
Byetta use	0.90 (0.60, 1.4)	0.63	1.1 (0.72, 1.7)	0.65
Antihypertensive medications	0.93 (0.72, 1.2)	0.56	0.77 (0.59, 1.02)	0.064
Lisinopril use	0.71 (0.55, 0.93)	0.014	0.74 (0.56, 0.97)	0.031
Losartan use	1.2 (0.83, 1.9)	0.30	1.09 (0.71, 1.7)	0.70
Furosemide use	2.2 (1.6, 2.9)	< 0.001	1.9 (1.4, 2.5)	< 0.001
Hydrochlorothiazide use	0.60 (0.45, 0.79)	< 0.001	0.57 (0.43, 0.76)	< 0.001
Spironolactone use	3.5 (2.4, 5.2)	< 0.001	3.1 (2.0, 4.6)	< 0.001
Amlodipine use	0.83 (0.59, 1.2)	0.30	0.74 (0.51, 1.07)	0.11
Metoprolol use	1.00 (0.75, 1.3)	0.99	0.87 (0.64, 1.2)	0.37
Carvedilol use	1.7 (0.96, 3.0)	0.071	1.6 (0.89, 3.0)	0.12
Antilipidemic medications	0.66 (0.51, 0.85)	0.001	0.58 (0.45, 0.76)	< 0.001
Rosuvastatin use	0.78 (0.48, 1.3)	0.33	0.66 (0.40, 1.1)	0.12
Atorvastatin use	0.70 (0.51, 0.96)	0.029	0.62 (0.44, 0.86)	0.004
Simvastatin use	0.66 (0.48, 0.91)	0.011	0.61 (0.44, 0.85)	0.003
Pravastatin use	0.80 (0.48, 1.3)	0.39	0.75 (0.44, 1.3)	0.28
Gemfibrozil use	0.85 (0.42, 1.7)	0.66	0.92 (0.44, 1.9)	0.82
Fenofibrate use	0.82 (0.53, 1.3)	0.38	0.73 (0.47, 1.1)	0.18
Aspirin use	0.74 (0.56, 0.98)	0.037	0.58 (0.43, 0.78)	< 0.001

¹Adjusted for age at time of biopsy, gender, race and body mass index. CKD: Chronic kidney disease; IBD: Inflammatory bowel disease; DVT: Deep venous thrombosis; OR: Odds ratio; CI: Confidence interval.