Optimal dosing time of Dachengqi decoction for protection of extrapancreatic organs in rats with experimental acute pancreatitis

Figure 1 Estimated concentration-time curves of eight components of Dachengqi decoction in the four groups. Twenty-four male Sprague-Dawley rats were randomly divided into SOG₁ and three model groups (MG_1, MG_2, and MG₃), and orally dosed with Dachengqi decoction (DCQD) (10 g/kg). Blood samples were collected via the tail vein at 10 min, 20 min, 40 min, 1 h, 2 h, 4 h, 8 h, 12 h, and 24 h after a single dose of DCQD to detect its main components. SOG₁: Sham-operated group with the dosing time at 4 h after operation. MG₁, MG₂, and MG₃: rats were dosed orally with DCQD at 4 h, 12 h, and 24 h after AP induction, respectively.