Intestinal dysbiosis in pediatric Crohn's disease patients with IL10RA mutations

doi:10.3748/wjg.v26.i22.3098

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 14, 2020; 26(22): 3098-3109
Published online Jun 14, 2020. doi: 10.3748/wjg.v26.i22.3098

Table 1 Clinical characteristics of the study population

	IL10RA	CD	HC	P value¹
Number of samples	17	17	26
Demographics
Age (mean ± SD, yr)	1.00 ± 0.68	8.92 ± 4.80	1.61 ± 1.71	< 0.001
Sex (M/F)	10/7	11/6	17/9	0.724
Weight and BMI
Weight (mean ± SD, kg)	7.31 ± 2.58	27.18 ± 13.04	NA	< 0.001
BMI (mean ± SD)	14.53 ± 2.20	15.25 ± 2.44	NA	0.6175
Disease activity
CRP (mean ± SD, mg/L)	40.65 ± 28.13	34.06 ± 31.92	NA	0.4486
wPCDAI (mean ± SD)	52.21 ± 17.65	40.88 ± 20.02	NA	0.1253
SES-CD (mean ± SD)	20.56 ± 7.56	12.94 ± 8.60	NA	0.0158
MINI index (mean ± SD)	19.88 ± 4.96	16.47 ± 2.92	NA	0.0027
Disease duration and anemia
Disease duration (mean ± SD, mo)	9.93 ± 7.75	7.10 ± 9.30	NA	0.0706
Disease location
Ileum only (%)	0 (0)	3 (18)	NA	< 0.001
Colon only (%)	17 (100)	3 (18)	NA
Both (%)	0 (0)	11 (64)	NA
Disease behaviour
Montreal classification B1 (%)	11 (65)	15 (88)	NA	0.106
Montreal classification B2 (%)	5 (29)	2 (12)	NA	0.203
Montreal classification B3 (%)	4 (24)	0 (0)	NA	0.033
Montreal classification P (%)	16 (94)	4 (24)	NA	< 0.001
Serology
IL6 (mean ± SD, pg/mL)	122.47 ± 152.22	37.50 ± 25.08	NA	0.0211
Birth and breast feeding
Cesarian section (%)	11 (65)	8 (47)	NA	0.300
Breast feeding (%)	14 (82)	13 (76)	NA	0.671
IBD medication
Mesalazine (%)	11 (65)	11 (65)	NA	1.000
Steroids (%)	1 (6)	2 (12)	NA	0.542
Thalidomide (%)	4 (24)	0 (0)	NA	0.014
Other medication
Antibiotics (%)	13 (76)	13 (76)	NA	1.000
Proton pump inhibitors (%)	1 (6)	9 (53)	NA	0.001
Marzulene-S (%)	1 (6)	1 (6)	NA	1.000
Self-reported diets
Amino acid formula (%)	2 (12)	0 (0)	NA	0.089
Extensive hydrolyzed formula (%)	3 (18)	1 (6)	NA	0.277
Other diet (%)	12 (71)	10 (59)	NA	0.473

¹P value for the comparison between IL10RA group and CD group. IL10RA: IL10RA group; CD: Crohn's disease group; HC: Healthy control group; NA: Not applicable; BMI: Body mass index; CRP: C-reactive protein; wPCDAI: Weighted pediatric Crohn's disease activity index; SES-CD: Simple endoscopic score for Crohn's disease; MINI: Mucosal-inflammation non-invasive; IL6: Interleukin 6.

Citation: Xue AJ, Miao SJ, Sun H, Qiu XX, Wang SN, Wang L, Ye ZQ, Zheng CF, Huang ZH, Wang YH, Huang Y. Intestinal dysbiosis in pediatric Crohn's disease patients with IL10RA mutations. World J Gastroenterol 2020; 26(22): 3098-3109
URL: https://www.wjgnet.com/1007-9327/full/v26/i22/3098.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i22.3098