Single-nucleotide polymorphisms based genetic risk score in the prediction of pancreatic cancer risk

Table 1 Information of single nucleotide polymorphisms for calculating genetic risk score

Chromosome	SNP	Region	Related-gene	Previous GWAS study
				OP1	RA	OR	RAF
1	rs10919791	1q32.1	NR5A2	EU	A	0.77	0.19
5	rs2736098	5p15.33	TERT, CLPTM1L	EU	T	0.8	NA1
5	rs401681	5p15.33	CLPTM1L	EU	T	1.19	0.49
5	rs2255280	5p13.1	DAB2	CH	G	0.81	0.32
6	rs2317900	6p25.3	FOXQ1	JA	C	1.288	0.41
7	rs6971499	7q32.3	LINC-PINT	EU	C	0.79	NA1
7	rs7779540	7q36.2	DPP6	JA	A	3.69	0.17
7	rs167020	7q36.3	SHH	EU	A	1.17	0.3
8	rs1561927	8q24.21	MIR1208, PVT1	EU	C	0.87	NA1
9	rs2073828	9q34.2	ABO	EU	A	0.85	0.37
9	rs505922	9q34.2	ABO	EU	C	1.2	0.35
10	rs12413624	10q26.11	PRLHR	CH	T	1.23	0.42
12	rs792864	12p11.21	BICD1	JA	A	0.71	0.24
13	rs9581943	13q12.2	PDX1	EU	A	1.46	NA1
13	rs4885093	13q22.1	NA	CH	C	1.25	0.5
13	rs9543325	13q22.1	NA	EU	C	1.26	0.37
16	rs7190458	16q23.1	BCAR1, CTRB1, CTRB2	EU	A	1.46	NA1
21	rs372883	21q21.3	BACH1	CH	C	0.79	0.39
21	rs1547374	21q22.3	TFF1	CH	G	0.79	0.4
22	rs16986825	22q12.1	ZNRF3	EU	T	1.18	NA1
22	rs5768709	22q13.32	FAM19A5	CH	G	1.25	0.28

¹Not available. These loci were not included in the final calculation of genetic risk score. OP: Original genome-wide association study population; RA: Risk allele; OR: Odds ratio from genome-wide association studies; RAF: Risk allele frequency in our study; EU: European; JA: Japanese; CH: Chinese; GWAS: Genome-wide association studies.