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©The Author(s) 2020.
World J Gastroenterol. Jun 14, 2020; 26(22): 3056-3075
Published online Jun 14, 2020. doi: 10.3748/wjg.v26.i22.3056
Published online Jun 14, 2020. doi: 10.3748/wjg.v26.i22.3056
Table 1 Pharmacokinetic parameters of the eight components of Dachengqi decoction in serum (n = 6)
Parameter | SOG1 | MG1 | MG2 | MG3 |
Emodin | ||||
AUC 0-t | 1605.0 ± 1029.5 | 359.3 ± 187.1a | 362.5 ± 67.4 | 427.5 ± 299.3 |
T 1/2z | 5.2 ± 1.4 | 18.9 ± 12.5a | 9.0 ± 3.2 | 22.6 ± 9.0 |
T max | 0.6 ± 0.3 | 3.5 ± 1.6a | 3.5 ± 1.6 | 0.3 ± 0dc |
C max | 620.733 ± 477.0 | 34.1 ± 22.5a | 29.8 ± 8.8 | 125.2 ± 90.9dc |
Aloe-emodin | ||||
AUC 0-t | 19206.1 ± 7275.8 | 11860.0 ± 4393.20 | 20181.9 ± 7660.2 | 37303.2 ± 13970.9d |
T 1/2z | 7.0 ± 1.9 | 5.4 ± 2.1 | 6.4 ± 0.8 | 8.1 ± 5.4 |
T max | 1.6 ± 1.6 | 1.4 ± 0.7 | 3 ± 1.2 | 0.7 ± 0.3c |
C max | 3797.0 ± 727.7 | 2203.9 ± 1156.1 | 2398.4 ± 708.9 | 8349.5 ± 3969.4dc |
Rhein | ||||
AUC 0-t | 31571.7 ± 8961.8 | 13308.8 ± 8524.4a | 61966.5 ± 18335.3b | 38030.3 ± 22227.7dc |
T 1/2z | 4.1 ± 1.5 | 6.5 ± 2.3 | 4.8 ± 0.8 | 20.8 ± 10.0dc |
T max | 0.8 ± 0.2 | 6.5 ± 2.3a | 1.7 ± 0.7b | 1.6 ± 1.6d |
C max | 11807.5 ± 2771.1 | 2204.3 ± 353.4a | 9245.7 ± 1284.0b | 11113.2 ± 5342.5d |
Chrysophanol | ||||
AUC 0-t | 29977.3 ± 7570.0 | 15682.3 ± 5428.0a | 28337.7 ± 8880.5b | 26358.6 ± 4312.1d |
T 1/2z | 5.7 ± 1.5 | 4.8 ± 1.0a | 4.7 ± 10.0 | 6.9 ± 4.5 |
T max | 1.4 ± 0.7 | 3.3 ± 3.2a | 1.5 ± 0.6b | 1.8 ± 1.7 |
C max | 7766.1 ± 2796.1 | 2018.9 ± 1227.5a | 4153.7 ± 2621.4 | 4318.1 ± 2458.9 |
Rheochrysidin | ||||
AUC 0-t | 867.505 ± 867.5 | 3665.5 ± 1693.3a | 3032.0 ± 1011.6 | 1510.264 ± 727.3d |
T 1/2z | 6.1 ± 1.0 | 4.3 ± 1.2 | 4.3 ± 1.6 | 9.4 ± 1.5dc |
T max | 1 ± 0.7 | 1.9 ± 1.5 | 2.2 ± 1.4 | 1.5 ± 0.6 |
C max | 197.5 ± 64.0 | 728.8 ± 387.4a | 489.8 ± 176.2 | 172.9 ± 110.7d |
Naringin | ||||
AUC 0-t | 353.0 ± 261.0 | 6296.0 ± 1271.2a | 5449.1 ± 2183.0 | 2188.5 ± 752.5dc |
T 1/2z | 6.4 ± 0.8 | 4.1 ± 0.7a | 5.4 ± 1.3 | 5.8 ± 5.8 |
T max | 0.8 ± 0.2 | 1.8 ± 1.7 | 2.3 ± 1.3 | 2.5 ± 1 |
C max | 125.6 ± 121.0 | 806.2 ± 730.9a | 682.4 ± 380.4 | 257.6 ± 26.4d |
Naringenin | ||||
AUC 0-t | 3064.2 ± 829.9 | 6344.8 ± 1199.2a | 3051.6 ± 932.6b | 3926.0 ± 1014.2d |
T 1/2z | 7.368 ± 1.5 | 4.5 ± 1.7 | 10.9 ± 3.4b | 7.8 ± 1.4 |
T max | 0.9 ± 0.7 | 2.3 ± 1.0 | 1.6 ± 1.6 | 0.6 ± 0.1d |
C max | 634.2 ± 228.6 | 805.3 ± 113.8 | 488.9 ± 316.7 | 581.1 ± 161.7 |
Magnolol | ||||
AUC 0-t | 143.8 ± 35.0 | 34.8 ± 8.0a | 69.4 ± 14.8 | 64.2 ± 10.8 |
T 1/2z | 9.0 ± 6.2 | 10.6 ± 1.4 | 13.9 ± 2.5 | 24.5 ± 9.1d |
T max | 0.7 ± 0.3 | 0.8 ± 0.8 | 3.5 ± 1b | 0.5 ± 0.3c |
C max | 30.6 ± 19.8 | 5.3 ± 1.7a | 5.5 ± 0.9 | 12.8 ± 3.1 |
- Citation: Yao JQ, Zhu L, Miao YF, Zhu L, Chen H, Yuan L, Hu J, Yi XL, Wu QT, Yang XJ, Wan MH, Tang WF. Optimal dosing time of Dachengqi decoction for protection of extrapancreatic organs in rats with experimental acute pancreatitis. World J Gastroenterol 2020; 26(22): 3056-3075
- URL: https://www.wjgnet.com/1007-9327/full/v26/i22/3056.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i22.3056