Use of zebrafish embryos as avatar of patients with pancreatic cancer: A new xenotransplantation model towards personalized medicine

doi:10.3748/wjg.v26.i21.2792

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 7, 2020; 26(21): 2792-2809
Published online Jun 7, 2020. doi: 10.3748/wjg.v26.i21.2792

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Figure 3 Representative hematoxylin and eosin stained sections of zebrafish patient-derived xenografts. Visible morphologic alteration of the human pancreatic ductal adenocarcinoma nuclei (orange arrows) in zebrafish patient-derived xenografts exposed to Gemcitabine + nab-Paclitaxel and 5-Fluorouracil + Folinic acid + Oxaliplatin + Irinotecan could be associated with a chemotherapy damage. Control group shows normal nuclei (black arrows). GEM/nab-P: Gemcitabine + nab-Paclitaxel; FOLFOXIRI: 5-Fluorouracil + Folinic acid + Oxaliplatin + Irinotecan.

Citation: Di Franco G, Usai A, Funel N, Palmeri M, Montesanti IER, Bianchini M, Gianardi D, Furbetta N, Guadagni S, Vasile E, Falcone A, Pollina LE, Raffa V, Morelli L. Use of zebrafish embryos as avatar of patients with pancreatic cancer: A new xenotransplantation model towards personalized medicine. World J Gastroenterol 2020; 26(21): 2792-2809
URL: https://www.wjgnet.com/1007-9327/full/v26/i21/2792.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i21.2792