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©The Author(s) 2020.
World J Gastroenterol. Jun 7, 2020; 26(21): 2702-2714
Published online Jun 7, 2020. doi: 10.3748/wjg.v26.i21.2702
Published online Jun 7, 2020. doi: 10.3748/wjg.v26.i21.2702
Figure 1 A model of the differential transcription of REG genes in colon crypt cells in Crohn’s disease and ulcerative colitis.
Increased interleukin-22 induced transcriptions of REG1/3 in Crohn’s disease (orange solid arrows) are relatively attenuated in ulcerative colitis (orange dotted arrows), leading to CDX2-activated REG transcriptions in ulcerative colitis (black solid arrows), but not in Crohn’s disease (black dotted arrows). IL: Interleukin; TGF: Transforming growth factor; TLR: Toll-like receptor.
- Citation: Edwards JA, Tan N, Toussaint N, Ou P, Mueller C, Stanek A, Zinsou V, Roudnitsky S, Sagal M, Dresner L, Schwartzman A, Huan C. Role of regenerating islet-derived proteins in inflammatory bowel disease. World J Gastroenterol 2020; 26(21): 2702-2714
- URL: https://www.wjgnet.com/1007-9327/full/v26/i21/2702.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i21.2702