Use of zebrafish embryos as avatar of patients with pancreatic cancer: A new xenotransplantation model towards personalized medicine

Table 3 Results of exposure to chemotherapy in xenotransplanted zebrafish embryos

Mean relative tumor area					Mean difference				95%CI				P value
Control group	FOLFOXIRI	GEMOX	GEM/nab-P	GEM	k vs FOLFOXIRI	k vs GEMOX	k vs GEM/nab-P	k vs Gemcitabine	k vs FOLFOXIRI	k vs GEMOX	k vs GEM/nab-P	k vs Gemcitabine	k vs FOLFOXIRI	k vs GEMOX	k vs GEM/nab-P	k vs Gemcitabine
3.026	0.790	1.243	0.988	1.213	2.236	1.784	2.038	1.813	0.286 to 4.187	-0.167 to 3.734	-0.047 to 4.123	-0.198 to 3.823	0.020	0.081	0.057	0.087
1.964	0.755	1.188	0.529	1.674	1.209	0.776	1.435	0.290	-0.016 to 2.434	-0.522 to 2.073	0.099 to 2.771	-0.978 to 1.558	0.054	0.361	0.032	0.936
1.699	0.524	1.599	1.238	0.706	1.175	0.100	0.461	0.993	-0.026 to 2.376	-1.348 to 1.548	-0.645 to 1.567	-0.113 to 2.099	0.057	0.999	0.659	0.088
1.604	0.951	1.990	1.767	1.013	0.653	-0.385	-0.163	0.592	-0.452 to 1.759	-1.551 to 0.780	-1.269 to 0.942	-0.724 to 1.907	0.381	0.817	0.987	0.616
2.357	2.260	1.689	1.566	1.263	0.097	0.668	0.792	1.094	-2.112 to 0.261	-1.363 to 2.700	-0.679 to 2.262	-0.479 to 2.668	> 0.990	0.817	0.458	0.244
2.098	0.714	1.423	1.130	1.672	1.384	0.674	0.968	0.426	-2.112 to 0.261	-0.826 to 2.175	-0.411 to 2.346	-1.075 to 1.926	0.034	0.610	0.236	0.879
2.170	1.663	1.746	1.205	0.965	0.507	0.424	0.966	1.205	-2.112 to 0.261	-0.760 to 1.607	-0.478 to 2.409	0.022 to 2.388	0.560	0.770	0.270	0.040
1.224	0.489	1.802	1.189	1.221	0.735	-0.578	0.035	0.003	-2.112 to 0.261	-2.130 to 0.975	-1.311 to 1.382	-1.549 to 1.556	0.730	0.750	> 0.990	> 0.990
1.606	0.710	0.423	0.606	0.945	0.896	1.183	1.000	0.662	-2.112 to 0.261	-0.383 to 2.748	0.083 to 1.918	-0.417 to 1.740	0.057	0.183	0.029	0.342
1.046	0.575	1.037	0.468	0.514	0.471	0.009	0.579	0.533	-2.112 to 0.261	-1.094 to 1.113	-0.557 to 1.714	-0.586 to 1.650	0.643	> 0.990	0.506	0.563
2.669	1.203	1.207	1.428	1.371	1.466	1.462	1.241	1.298	-2.112 to 0.261	-1.407 to 4.331	-1.326 to 3.807	-1.268 to 3.864	0.338	0.492	0.537	0.499
1.371	0.852	0.705	1.383	1.077	0.520	0.666	-0.012	0.294	-0.667 to 1.706	-0.775 to 2.107	-1.452 to 1.429	-0.774 to 1.363	0.627	0.584	> 0.990	0.888
1.648	0.8481	0.8028	1.174	1.273	0.7996	0.8449	0.4737	0.3748	0.019 to 1.580	-0.030 to 1.720	-0.3717 to 1.319	-0.471 to 1.220	0.043	0.061	0.433	0.632
1.275	1.704	0.888	2.157	1.683	-0429	0.387	-0.882	-0.408	-1.975 to 1.117	-0.957 to 1.731	-2.428 to 0.664	-1.954 to 1.138	0.879	0.864	0.394	0.896
1.041	1.966	1.167	0.789	1.091	-0.926	-0.126	0.252	-0.050	-2.112 to 0.261	-1.356 to 1.104	-1.035 to 1.539	-1.281 to 1.180	0.162	> 0.990	0.963	> 0.990

k: Control group; GEM: Gemcitabine; GEMOX: Gemcitabine + Oxaliplatin; GEM/nab-P: Gemcitabine + nab-Paclitaxel; FOLFOXIRI: 5-Fluorouracil + Folinic acid + Oxaliplatin + Irinotecan.