Metabolomics profile in gastrointestinal cancers: Update and future perspectives

doi:10.3748/wjg.v26.i20.2514

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 28, 2020; 26(20): 2514-2532
Published online May 28, 2020. doi: 10.3748/wjg.v26.i20.2514

Table 4 Panel of altered metabolites’ levels identified in fecal water samples of gastrointestinal cancer patients versus healthy controls

	Fw
	CRC[83]	CRC[84]	CRC[86]	CRC[85]
4-aminohippurate			↓²
Acetate	↓	↓		↓
Alanine		↑¹	↓	↑
Beta-alanine			↓
Butyrate	↓	↓		↓
Cholate			↓
Deoxycholate			↓
Galactose			↓
Glucose		↓	↓
Glutamate		↑		↑
Glutamine		↓	↓
Glycerol			↓
Hexose-phosphate			↑
Isobutyrate			↑
Isoleucine		↑	↓	↑
Isovalerate			↑
Lactate		↑		↑
Leucine	↑	↑		↑
Litho deoxycholate			↓
Methanol			↓
Ornithine			↓
Phenylacetate
Proline	↑	↑
Propionate		↓		↓
Succinate		↑		↑
Taurine			↓
Valine		↑		↑
Xylose			↓

¹↑Higher metabolite levels in gastrointestinal cancers.

²↓Lower metabolite levels in gastrointestinal cancers. Fw: Fecal water; CRC: Colorectal cancer.

Citation: Nannini G, Meoni G, Amedei A, Tenori L. Metabolomics profile in gastrointestinal cancers: Update and future perspectives. World J Gastroenterol 2020; 26(20): 2514-2532
URL: https://www.wjgnet.com/1007-9327/full/v26/i20/2514.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i20.2514