Impact of GFRA1 gene reactivation by DNA demethylation on prognosis of patients with metastatic colon cancer

Figure 5 Overexpression of GFRA1b promotes the growth of RKO colon cancer cells in nude mice. A: Xenograft tumors in the GFRA1b-expressing and negative control (Ctrl) groups on the 29^th day post-transplantation. Four mice in the control group did not develop tumors; B: Comparison of the tumor weight in the GFRA1b-expressing and negative control groups (0.518 g vs 0.161 g; Mann-Whitney U-test, P = 0.036); C: Expression status of the GFRA1 protein in one representative tumor from the GFRA1b-expressing and negative control groups by Western blot. Ctrl: Control.