Plasma exchange in patients with acute and acute-on-chronic liver failure: A systematic review

Table 1 Participants, interventions, comparisons, outcomes and study design criteria used to define the research question for this systematic review

Variable	Description
Population	Humans diagnosed with liver failure (ALF/ACLF)
Intervention	Plasma exchange with or without other alternative liver support systems; no restrictions on dose, duration and type of plasma exchange
Comparator	Randomized controlled trials/Cohort studies: Standard medical treatment
	Case series/case reports: Nil
Outcome	All-cause mortality, changes in liver biochemistry, and survival in non-transplanted patients
Study design	Randomized Controlled Trials, Cohort studies, Case series, Case reports
Research question	Does plasmapheresis have an effect on all-cause mortality, changes in liver biochemistry, and survival in non-transplanted patients with ALF/ACLF, compared to standard medical treatment?

ALF: Acute liver failure; ACLF: Acute-on-chronic liver failure.