Impact of GFRA1 gene reactivation by DNA demethylation on prognosis of patients with metastatic colon cancer

Table 2 Results of multivariate analysis for survival factors in colon cancer patients

	All patients (n = 144)		Patients with metastatic CC (n = 89)
	Adjusted HR (95%CI)	P value	Adjusted HR (95%CI)	P value
Low dmGFRA1	0.49 (0.24-0.98)	0.044	0.41 (0.18-0.91)	0.029
Age	1.68 (0.83-3.40)	0.147	1.69 (0.77-3.73)	0.191
Sex	1.45 (0.76-2.76)	0.256	1.44 (0.71-2.91)	0.317
Location	2.60 (1.32-5.14)	0.006	3.22 (1.48-7.01)	0.003
Differentiation	1.95 (0.65-5.89)	0.235	2.02 (0.62-6.61)	0.246
Vascular embolus	0.32 (0.15-0.68)	0.003	0.33 (0.15-0.74)	0.007
Local invasion	1.27 (0.71-2.28)	0.421	1.16 (0.60-2.24)	0.668
Metastasis	4.92 (2.04-11.84)	0.000

CC: Colon cancer; HR: Hazard ratio; CI: Confidence interval.