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©The Author(s) 2020.
World J Gastroenterol. Jan 14, 2020; 26(2): 184-198
Published online Jan 14, 2020. doi: 10.3748/wjg.v26.i2.184
Published online Jan 14, 2020. doi: 10.3748/wjg.v26.i2.184
Table 1 Comparison of GFRA1 demethylation-high proportion by MethyLight for colon carcinoma tissues from 144 patients with various clinicopathological characteristics
dmGFRA11-high cases | dmGFRA1-low cases | dmGFRA1-high proportion (%) | P value1 | ||
Age (yr) | < 60 | 35 | 25 | 58.3 | 0.091 |
≥ 60 | 37 | 47 | 44.0 | ||
Sex | Male | 42 | 46 | 47.7 | 0.494 |
Female | 30 | 26 | 53.6 | ||
Location | Sigmoid | 33 | 40 | 45.2 | 0.243 |
Others | 39 | 32 | 54.9 | ||
Differentiation | Poor | 12 | 1 | 92.3 | 0.0022 |
Moderate/well | 62 | 69 | 45.8 | ||
Vascular embolus | Negative | 58 | 65 | 47.2 | 0.098 |
Positive | 14 | 7 | 66.7 | ||
pTNM stage | I/II | 33 | 39 | 45.8 | 0.314 |
III/IV | 38 | 32 | 54.3 | ||
Local invasion | T1-2 | 5 | 6 | 45.5 | |
T3 | 44 | 27 | 62.0 | 0.0043 | |
T4 | 22 | 38 | 36.7 | ||
Lymphatic metastasis | N0 | 32 | 41 | 43.8 | 0.134 |
N1-3 | 40 | 31 | 56.3 | ||
Distant metastasis | M0 | 58 | 68 | 46.0 | 0.0212 |
M1 | 14 | 4 | 77.8 |
- Citation: Ma WR, Xu P, Liu ZJ, Zhou J, Gu LK, Zhang J, Deng DJ. Impact of GFRA1 gene reactivation by DNA demethylation on prognosis of patients with metastatic colon cancer. World J Gastroenterol 2020; 26(2): 184-198
- URL: https://www.wjgnet.com/1007-9327/full/v26/i2/184.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i2.184