Assessment of lncRNA GAS5, lncRNA HEIH, lncRNA BISPR and its mRNA BST2 as serum innovative non-invasive biomarkers: Recent insights into Egyptian patients with hepatitis C virus type 4

Table 2 Pearson’s correlation between studied LncRNA GAS5, LncRNA BISPR, LncRNA HEIH, mRNA BST2 and clinical parameters in the different studied groups

Variables	LncRNA Gas5		LncRNA BISPR		LncRNA HEIH		MRNA BST2
	r	P value	r	P value	r	P value	r	P value
Age (yr)	0.051	0.53	0.138	0.09	0.095	0.24	-0.043	0.60
Sex (M/F)	0.070	0.39	-0.043	0.60	0.037	0.65	-0.062	0.44
ALT (IU/L)	0.332	0.001c	0.287	0.001c	-0.072	0.37	-0.194	0.01a
AST (IU/L)	0.016	0.04a	0.141	0.08	-0.222	0.006b	0.008	0.92
Albumin (g/dL)	-0.454	0.001c	-0.419	0.001c	-0.0157	0.05	0.434	0.001c
Bilirubin (mg/dL)	0.088	0.28	0.049	0.54	0.034	0.67	-0.083	0.31
ALP (IU/L)	0.589	0.001c	0.517	0.001c	0.044	0.59	-0.346	0.001c
INR	0.136	0.09	0.172	0.03a	-0.062	0.45	0.021	0.79
AFP	0.476	0.001c	0.176	0.03a	0.640	0.001c	-0.347	0.001c
PT	0.405	0.001c	0.300	0.001c	0.081	0.32	-0.206	0.01a
Viral load	0.276	0.001c	0.374	0.001c	0.056	0.49	-0.284	0.001c
(log copies/mL)
LncRNA Gas5			0.607	0.001c	0.318	0.001c	-0.465	0.001c
LncRNA BST2	0.607	0.001c			0.040	0.62	-0.371	0.001c
LncRNA HEIH	0.318	0.001c	0.040	0.62			-0.235	0.004b
mRNA BST2	-0.465	0.001c	-0.371	0.001c	-0.235	0.004b

^aP < 0.05,

^bP < 0.01,

^cP < 0.001, indicates statistical significance. ALT: Alanine aminotransferases; AST: Aspartate aminotransferases; ALP: Alkaline phosphatase; INR: International normalized ratio AFP: Alfa fetoprotein; PT: Prothrombin time.