Gamma-glutamyl transferase and cardiovascular risk in nonalcoholic fatty liver disease: The Gut and Obesity Asia initiative

Figure 1 Cardiovascular disease risks and fibrosis stages. Median (interquartile range [IQR]) 10-year cardiovascular disease risks were fibrosis stages (F) 0 = 3.3 (1.5-6.6), F1 = 5.5 (2.4-10.4), F2 = 6.2 (2.6-9.9), F3 = 8.8 (4.8-13.4), and F4 = 10.3 (6.7-14.1) with statistically significant difference (P < 0.001). Post hoc analysis found that the significant differences were between F0 and F1, F0 and F2, F0 and F3, F0 and F4, F1 and F3, F1 and F4, F2 and F3, F2 and F4. Nonalcoholic fatty liver disease patients with advanced fibrosis (F3-4) had a higher median 10-year cardiovascular disease (CVD) risk according to QRISK2 (P < 0.001).