Computed tomography vs liver stiffness measurement and magnetic resonance imaging in evaluating esophageal varices in cirrhotic patients: A systematic review and meta-analysis

Table 3 Overview of results of meta-analysis

Group	LSM for presence of EV	LSM for presence of HREV	CT for presence of EV	CT for presence of HREV	MRI for presence of EV	MRI for presence of HREV
Diagnostic threshold
Spearman correlation coefficient	0.36	0.21	-0.2	0.12	0.27	0.57
P value	0.19	0.5	0.27	0.58	0.56	0.11
SROC
AUSROC (95%CI)	0.86 (0.83-0.89)	0.85 (0.81-0.88)	0.91 (0.88-0.93)	0.94 (0.91-0.96)	0.86 (0.83-0.89)	0.83 (0.79-0.86)
I2	97.43%	97.13%	97.17%	98.30%	86.41%	91.64%
P value	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01
Sensitivity
Summary sensitivity (95%CI)	0.84 (0.78-0.89)	0.81 (0.75-0.86)	0.91 (0.87-0.94)	0.88 (0.82-0.92)	0.81 (0.76-0.86)	0.80 (0.72-0.86)
I2	82.63%	70.93%	88.46%	87.06%	33.57%	67.03%
P value	< 0.01	< 0.01	< 0.01	< 0.01	0.17	< 0.01
Specificity
Summary specificity (95%CI)	0.71 (0.60-0.80)	0.73 (0.66-0.80)	0.75 (0.68-0.82)	0.87 (0.81-0.92)	0.82 (0.70-0.89)	0.72 (0.62-0.80)
I2	86.56%	91.65%	80.58%	93.26%	74.53%	83.17%
P value	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01
PLR
Summary PLR (95%CI)	2.91 (2.08-4.06)	3.04 (2.38-3.89)	3.67 (2.73-4.94)	6.90 (4.54-10.49)	4.44 (2.74-7.21)	2.83 (2.11-3.80)
I2	82.66%	85.63%	83.81%	91.04%	31.66%	51.94%
P value	< 0.01	< 0.01	< 0.01	< 0.01	0.01	< 0.01
NLR
Summary NLR (95%CI)	0.22 (0.16-0.30)	0.26 (0.19-0.34)	0.12 (0.08-0.18)	0.14 (0.09-0.21)	0.23 (0.18-0.28)	0.28 (0.21-0.38)
I2	79.49%	68.30%	88.94%	91.10%	<0.01%	43.01%
P value	< 0.01	< 0.01	< 0.01	< 0.01	0.53	0.08
Summary DOR (95%CI)	13.01 (7.83-21.64)	11.93 (7.89-18.03)	30.98 (16.02-59.91)	49.99 (25.38-98.43)	19.58 (11.39-33.66)	10.00 (6.63-15.09)

A significant heterogeneity was found in all analyses. There were no threshold effects in all analyses (P > 0.05). CT had the largest area under the summary receiver operating characteristic curves in both of the diagnosis of EV and prediction of HREV. SROC: Summary receiver operating characteristic curves; CT: Computed tomography; EV: Esophageal varices; HREV: High bleeding risk esophageal varices; MRI: Magnetic resonance imaging; LSM: Liver stiffness measurement; PLR: Positive likelihood ratio; NLR: Negative likelihood ratio; DOR: Diagnostic odds ratio; AUSROC: Area under the summary receiver operating characteristic curves.