Computed tomography vs liver stiffness measurement and magnetic resonance imaging in evaluating esophageal varices in cirrhotic patients: A systematic review and meta-analysis

Table 2 Characteristics of articles using computed tomography imaging to predict HREV

Ref.	Study design	Total patients	Mean age (yr)	Male (%)	Etiology (%)	Child-Pugh class (%)	CT scanner	Cut-off value (mm)	Interval between CT and endoscopy	Presence of HREV
										TP	FP	FN	TN
Deng et al[34], 2016	Retrospective	52	55.4	64	Alcohol (30.8); HBV (25.0); HBV + Alcohol (9.6); HCV (3.8); HBV + HCV (1.9); Others (28.9)	A (49.0); B (39.2); C (11.8)	NR	EVD 3.9	NR	35	4	4	9
Dessouky et al[35], 2013	Prospective	137	58.7	53	HCV (67.9); HBV (19.7); HBV + HCV (10.2); Steato-hepatitis (2.2)	A (55); B (31); C (14)	16-slice	EVD 3.0	Within 24 h	38	0	0	99
Elalfy et al[36], 2016	Retrospective	124	56.5	52	HCV (100)	A (62.9); B (37.1)	16-slice	PVD 12.5	NR	33	49	13	29
Kim et al[39], 2008	Retrospective	110	61	74	HBV (60.9); HCV (29.1) Alcohol (6.4); HBV + HCV (1.8); Others (1.8)	A (63.6); B (26.4); C (10.0)	16-slice	EVD 2.0	8.2 d1	123	15	9	61
										113	2	19	59
										115	15	17	61
Kim et al[40], 2020	Retrospective	104	59	74	HBV (72.1); HCV (12.5); Alcohol (6.7); Others (8.7)	A (41.3); B (30.8); C (27.9)	16 or 64-slice	EVD 2.0	Within 4 wk	34	3	3	70
										36	10	1	63
										32	4	5	69
Kim et al[41], 2007	Prospective	90	54.8	72	HBV (73.3); HCV (21.1); Alcohol (2.2); Others (3.3)	A (81.1); B (18.9)	16-slice	Grade 2 and Grade 33	Within 4 h	28	11	2	49
										28	5	2	55
										27	9	3	51
										27	2	3	58
Kim et al[42], 2007	Retrospective	67	56.2	58	HCV (35.8); HBV (22.4); Alcohol (22.4); HBV + HCV (9.0); Others (10.4)	A (23.9); B (37.3); C (38.8)	NR	EVD 3.0	Within 4 wk	11	9	1	46
										11	9	1	46
Lipp et al[43], 2011	Retrospective	299	55.2	65	NR	NR	4 or 16 or 64-slice	EVD 4.0	Within 12 wk	18	11	12	96
										12	4	22	127
Perri et al[45], 2008	Prospective	101	NR	63	Viral (21.8); Alcohol (18.8); Biliary (17.8); NASH (14.9); Others (26.7)	A (44.6); B (39.6); C (15.8)	4-slice or higher	EVD 5.0	2 d2	23	5	18	55
										27	8	14	52
Yu et al[47], 2011	Retrospective	109	55.9	55	HCV (46.8); Alcohol (17.4); HBV (6.4); Others (29.4)	NR	16 or 64-slice	EVD 2.0	NR	25	24	1	59
										25	18	1	65
										23	41	3	42
										23	17	3	66

¹Mean.

²Median.

³Grade 2: Varices show beaded appearance; Grade 3: Varices run in oblique course and are tortuous with tumorlike appearance. EVD: Esophageal varices diameter; NR: Not reported; PVD: Portal vein diameter; HBV: Hepatitis B virus; HCV: Hepatitis C virus; NASH: Nonalcoholic steatohepatitis; CT: Computed tomography; HREV: High-bleeding-risk esophageal varices; TP: True positive; FP: False positive; FN: False negative; TN: True negative.