Computed tomography vs liver stiffness measurement and magnetic resonance imaging in evaluating esophageal varices in cirrhotic patients: A systematic review and meta-analysis

Table 1 Characteristics of articles using computed tomography imaging to diagnose esophageal varices

Ref.	Study design	Total patients	Mean age (yr)	Male (%)	Etiology (%)	Child-Pugh class (%)	CT scanner	Interval between CT and endoscopy	Presence of EV
									TP	FP	FN	TN
Cansu et al[33], 2014	Prospective	50	56.8	54	HBV (40.0); HCV (30.0); Biliary (6.0); HBV + HCV (4.0); Alcohol (4.0%); Others (16.0)	A (52.0); B (36.0); C (12.0)	16-slice	Within 4 wk	33	2	0	15
	Prospective	42	56.2	69	HBV (45.2); HCV (23.8); Alcohol (4.8); HBV + HCV (2.4); Biliary (2.4); Others (21.4)	A (38.1); B (31.0); C (31.0)	16-slice	Within 4 wk	25	3	8	6
Deng et al[34], 2016	Retrospective	52	55.4	63.5	Alcohol (30.8); HBV (25.0); HBV + Alcohol (9.6); HCV (3.8); HBV + HCV (1.9); Others (28.9)	A (49.0); B (39.2); C (11.8)	NR	NR	43	2	2	5
Desso-uky et al[35], 2013	Prospective	137	58.7	53.3	HCV (67.9); HBV (19.7); HBV + HCV (10.2); Steatohepatitis (2.2)	A (55); B (31); C (14)	16-slice	Within 24 h	89	1	1	46
Elalfy et al[36], 2016	Retrospective	124	56.5	52	HCV (100)	A (62.9); B (37.1)	16-slice	NR	70	4	4	46
Elkammash et al[37], 2015	NR	112	51.4	68.8	HBV (46); HCV (44); Schisto-somiasis (10)	NR	64-slice	Within 2 wk	97	0	2	13
									99	0	0	13
Jiang et al[38], 2015	NR	89	57	64	HBV (71.9); Alcohol (11.2); HCV (7.9); Biliary (5.6); Drug (1.1); Unknown (2.3)	NR	64-slice	NR	58	3	8	20
Kim et al[40], 2020	Retrospective	104	59	74	HBV (72.1); HCV (12.5); Alcohol (6.7); Others (8.7)	A (41.3); B (30.8); C (27.9)	16 or 64-slice	Within 4 wk	180	9	8	11
									169	9	19	11
									172	15	16	5
Kim et al[41], 2007	Prospective	90	54.8	72.2	HBV (73.3); HCV (21.1); Alcohol (2.2); Others (3.3)	A (81.1); B (18.9)	16-slice	Within 4 h	50	15	3	22
									47	12	6	25
									46	13	7	24
									46	8	7	29
Kim et al[42], 2007	Retrospective	67	56.2	58.2	HCV (35.8); HBV (22.4); Alcohol (22.4); HBV + HCV (9.0); Others (10.4)	A (23.9); B (37.3); C (38.8)	NR	Within 4 wk	29	6	13	19
									27	3	15	22
Lipp et al[43], 2011	Retrospective	299	55.2	64.9	NR	NR	4 or 16 or 64-slice	Within 12 wk	54	24	7	52
									41	17	30	77
Moftah et al[44], 2014	NR	54	56.8	74.1	NR	NR	8-slice	NR	48	0	2	4
Perri et al[45], 2008	Retrospective	101	NR	63.4	Viral (21.8); Alcohol (18.8); Biliary (17.8); NASH (14.9); Others (26.7)	A (44.6); B (39.6); C (15.8)	4-slice or higher	2 d1	73	10	6	12
									68	12	11	10
Wu et al[46], 2009	Prospective	50	57.7	60	HBV (76); Autoimmune (2); Others (22)	A (26.0); B (62.0); C (12.0)	16-slice	Within 4 wk	39	3	2	6
									40	5	1	4
Yu et al[47], 2011	Retrospective	109	55.9	55	HCV (46.8); Alcohol (17.4); HBV (6.4); Others (29.4)	NR	16 or 64-slice	NR	50	10	12	37
									50	12	12	35
									49	24	13	23
									47	17	15	30
Zhao et al[48], 2016	Retrospective	143	52.39	67.1	HBV (70.6); Alcohol (11.2); Autoimmune (4.9); HCV (3.5); Biliary (3.5); Others (6.3)	A (37.8); B (33.6); C (28.7)	64-slice	3.4 d2	11	3	1	27
									2
Zhu et al[49], 2009	Retrospective	127	45.2	75.6	HBV (74.8); Alcohol (10.2); HCV (4.7); Others (10.2)	A (37.8); B (37.0); C (25.2)	4-slice	Within 4 wk	72	15	14	26
									67	11	19	30

¹Median.

²Mean. NR: Not reported; HBV: Hepatitis B virus; HCV: Hepatitis C virus; NASH: Nonalcoholic steatohepatitis; CT: Computed tomography; EV: Esophageal varices; TP: True positive; FP: False positive; FN: False negative; TN: True negative.