Copyright
©The Author(s) 2020.
World J Gastroenterol. Apr 21, 2020; 26(15): 1758-1774
Published online Apr 21, 2020. doi: 10.3748/wjg.v26.i15.1758
Published online Apr 21, 2020. doi: 10.3748/wjg.v26.i15.1758
Figure 4 Mdivi-1 administration inhibits mitochondrial fission and reactive oxygen species generation in Caco-2 hypoxia/reoxygenation cells.
A: Deep Red FM in Caco-2 cells (scale bar = 10 μm); B, C: Dynamin-related protein 1 and dynamin-related protein 1 Ser637 expression upon mdivi-1 administration (n = 3); D: MitoSOX assay in Caco-2 cells (scale bar = 10 μm). cP < 0.001 compared with the control group; eP < 0.01 compared with the hypoxia/reoxygenation group. DRP1: Dynamin-related protein 1; PINK1: PTEN induced kinase 1; H/R: Hypoxia/reoxygenation.
- Citation: Qasim W, Li Y, Sun RM, Feng DC, Wang ZY, Liu DS, Yao JH, Tian XF. PTEN-induced kinase 1-induced dynamin-related protein 1 Ser637 phosphorylation reduces mitochondrial fission and protects against intestinal ischemia reperfusion injury. World J Gastroenterol 2020; 26(15): 1758-1774
- URL: https://www.wjgnet.com/1007-9327/full/v26/i15/1758.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i15.1758