Chemoprevention of gastric cancer development after Helicobacter pylori eradication therapy in an East Asian population: Meta-analysis

Table 2 Gastric cancer development and histological characteristics

Ref.	Design	Follow-up periods (yr)	Eradicated group		Non-eradicated control group		Eradicated group		Non-eradicated control group
			Cancer/ Total	Cancer incidence, /100000 PY	Cancer/ Total	Cancer incidence, /100000 PY	Intestinal type	Diffuse type	Intestinal type	Diffuse type
Patients after resection for gastric cancer
Fukase et al[31], 2006	RCT	3	9/272	1102.9	24/272	2941.2	9	0	23	1
Choi et al[32], 2018	RCT	5.9	14/194	1223.1	27/202	2265.5	14	0	25	1
Choi et al[33,69]	RCT	6	18/442	678.7	36/456	1315.8	13	5	26	8
Uemura et al[70], 1997	Cohort	3	0/65	0	6/67	2985.1	0	0	6	0
Nakagawa et al[71], 2006	Cohort	2	8/356	864.3	129/2469	2902.7	NA	NA	NA	NA
Shiotani et al[72], 2008	Cohort	2.75	9/80	4090.9	1/11	3305.8	9	0	1	0
Han et al[73], 2011	Cohort	2.7	4/94	1576	2/22	3367	NA	NA	NA	NA
Kim et al[74], 2011	Cohort	5.1	0/28	0	5/27	3631.1	0	0	NA	NA
Maehata et al[75], 2012	Cohort	3	15/177	2824.9	13/91	4761.9	14	1	13	0
Seo et al[76], 2013	Cohort	2.27	6/61	4333.1	3/13	10166	NA	NA	NA	NA
Kato et al[77], 2013	Cohort	2.23	24/263	4092.1	6/105	2562.5	NA	NA	NA	NA
Bae et al[78], 2014	Cohort	5	34/485	1402.1	24/182	2637.4	NA	NA	NA	NA
Kim et al[79], 2014	Cohort	4.3	2/49	770.1	16/107	3250.7	NA	NA	NA	NA
Kwon et al[80], 2014	Cohort	3.4	18/214	2473.9	13/69	5541.3	8	2	6	4
Jung et al[27], 2015	Cohort	3.36	21/506	1235.2	10/169	1761.1	NA	NA	NA	NA
Lim et al[28], 2015	Cohort	3.1	7/236	956.8	6/276	701.3	NA	NA	NA	NA
Kim et al[81], 2016	Cohort	2.5	3/120	902.5	1/42	872.1	NA	NA	NA	NA
Ami et al[82], 2017	Cohort	4.47	25/212	2638.1	1/14	1598	NA	NA	NA	NA
Kwon et al[29], 2017	Cohort	3.725	33/368	2255.9	8/27	7454	10	6	3	2
Chung et al[30], 2017	Cohort	5.125	17/167	1986.3	7/18	7588.1	NA	NA	NA	NA
Han et al[83], 2018	Cohort	5	12/212	1132.1	18/196	1836.7	11	1	18	0
Cho et al[17], 2013	RCT	3	3/87	1149.4	1/82	406.5	1	2	1	0
Patients with gastritis
Wong et al[18], 2004	RCT	7.5	7/817	114.2	11/813	180.4	NA	NA	NA	NA
Ma et al[23], You et al[84] and Li et al[85]	RCT	14.3	34/1130	210.4	52/1128	322.4	NA	NA	NA	NA
Wong et al[19], 2012	RCT	2	6/510	588.2	3/514	291.8	6	0	2	1
Zhou et al[24], 2014, Leung et al[86], 2004	RCT	10	2/276	72.5	7/276	253.6	NA	NA	NA	NA
Saito et al[22], 2000	Cohort	2	0/32	0	4/32	6250	0	0	4	0
Uemura et al[52], 2001	Cohort	7.7	0/253	0	36/993	424.4	0	0	23	13
Kato et al[87], 2006	Cohort	5.9-7.7	23/1788	218	44/1233	467.2	19	4	32	12
Takenaka et al[88], 2007	Cohort	3.17	6/1519	121.5	5/288	598.7	4	2	4	1
Ogura et al[89], 2008	Cohort	3.2	6//404	464.1	13/304	1379.5	3	3	11	2
Kim et al[90], 2008	Cohort	9.4	1/476	22.3	4/977	43.6	0	1	3	1
Mabe et al[53], 2009	Cohort	5.6	47/3781	222	9/352	491.7	35	10	5	4
Yanaoka et al[25], 2009	Cohort	9.3	5/473	113.7	55/3656	161.8	4	1	36	19
Watanabe et al[26], 2012	Cohort	5.4	0/327	0	7/496	261.4	0	0	1	6
Lee et al[20], 2013	Cohort	5	15/4121	72.8	16/4121	77.7	NA	NA	NA	NA
Shichijo et al[21], 2015	Cohort	6.7 ± 4.7	4/260	229.6	13/203	955.8	NA	NA	NA	NA
Take et al[91-94]	Cohort	9.9	24/1133	214	6/89	681	14	10	5	1

NA: Not available; RCT: Randomized control trial; PY: Person-year.