Meta-Analysis
Copyright ©The Author(s) 2020.
World J Gastroenterol. Apr 21, 2020; 26(15): 1820-1840
Published online Apr 21, 2020. doi: 10.3748/wjg.v26.i15.1820
Table 1 Characteristics of the studies
Ref.CountryPrimary or metachronous cancerDesignDisease at basementFollow-up periods (yr)Patients numberAge (yr)Sex (male/ female)Regimen of eradication therapyEradication rate (%)
Fukase et al[31], 2006JapanMetachronousRCTGastric cancer354468 (62-73)386/119LPZ(30)/AMPC(750)/CAM(200), BID, 7D75.0
Choi et al[32], 2018South KoreaMetachronousRCTGastric cancer5.939659298/104RPZ(10)/AMPC(1000)/CAM(500), BID 7D80.4
Choi et al[33,69]South KoreaMetachronousRCTGastric cancer689860.4594/283OPZ(20)/AMPC(1000)/CAM(500), BID 7D82.6
Uemura et al[70], 1997JapanMetachronousCohortGastric cancer313269 (44-85)97/351st: OPZ(20)/CAM(400) 14D, 2nd: OPZ(20)/AMPC(1500)/MNZ(500), BID 14D46.2
Nakagawa et al[71], 2006JapanMetachronousCohortGastric cancer22825NANANANA
Shiotani et al[72], 2008JapanMetachronousCohortGastric cancer2.751006967/13PPI/AMPC(750)/CAM(200), BID 7D81.3
Han et al[73], 2011South KoreaMetachronousCohortGastric cancer2.717661.8 (43-83)112/64NANA
Kim et al[74], 2011South KoreaMetachronousCohortGastric cancer5.15560.7 (43-81)36/19NA50.9
Maehata et al[75], 2012JapanMetachronousCohortGastric cancer326869 (49-90)194/74PPI/AMPC(750)/CAM(200), BID 7D78.2
Seo et al[76], 2013South KoreaMetachronousCohortGastric cancer2.27746255/19PPI/AMPC(1000)/CAM(500), BID 7-14D82.4
Kato et al[77], 2013JapanMetachronousCohortGastric cancer2.2336870.5953/305NANA
Bae et al[78], 2014South KoreaMetachronousCohortGastric cancer5100763 (28-88)785/222PPI/AMPC(750)/CAM(200), BID 7-14DNA
Kim et al[79], 2014South KoreaMetachronousCohortGastric cancer4.337464 (35-87)278/96PPI/AMPC(1000)/CAM(500), BID 7D72.1
Kwon et al[80], 2014South KoreaMetachronousCohortGastric cancer3.428359190/93PPI/AMPC(750)/CAM(200), BID 7D68.9
Jung et al[27], 2015South KoreaMetachronousCohortGastric cancer3.36104162.7773/268LPZ(30)/AMPC(1000)/CAM(500), BID 7-14DNA
Lim et al[28], 2015South KoreaMetachronousCohortGastric cancer3.193363.0 ± 9.51512/250NANA
Kim et al[81], 2016KoreaMetachronousCohortGastric cancer2.525767189/68PPI/AMPC(1000)/CAM(500), BID 7D86.3
Ami et al[82], 2017JapanMetachronousCohortGastric cancer4.4743869.4 ± 8.7421/118LPZ(30) or RPZ(10)/AMPC(750)/CAM(200), BID 7-14DNA
Kwon et al[29], 2017South KoreaMetachronousCohortGastric cancer3.72559063398/192RPZ(20)/AMPC(1000)/CAM(500), BID 7D81.8
Chung et al[30], 2017South KoreaMetachronousCohortGastric cancer5.12518567.4 (45-87)141/44PPI/AMPC/CAM, BID 7DNA
Han et al[83], 2018South KoreaMetachronousCohortGastric cancer556561440/125NANA
Cho et al[17], 2013South KoreaMetachronousRCTGastric cancer316956117/52RPZ(10)/AMPC(1000)/CAM(500), BID 7D77
Wong et al[18], 2004ChinaPrimaryRCTGastritis alone7.5163042.2 (35-65)880/750OPZ(20)/AMPC(750)/MNZ(400), BID 14D82.5
Ma et al[23], You et al[84] and Li et al[85]ChinaPrimaryRCTNon-gastric cancer14.3225847.11808/1603OPZ(20)/AMPC(1000), BID 7D66.2
Wong et al[19], 2012ChinaPrimaryRCTWith/without metaplasia2102453.0 (35-64)473/551PPI/AMCP(1000)/CAM(500), BID 7D71.3
Zhou et al[24], 2014, Leung et al[86], 2004ChinaPrimaryRCTNon-gastric cancer1055453.35 ± 8.49268/284OPZ(20)/AMPC(1000)/CAM(500), BID 7D88.9
Saito et al[22], 2000JapanPrimaryCohortGastric adenoma26479.2 (68-92)35/29OPZ(20)/AMCP(1000)/CAM(400), BID 7D75
Uemura et al[52], 2001JapanPrimaryCohortWith/without PU7.7152652.4869/657NANA
Kato et al[87], 2006JapanPrimaryCohortWith/without PU5.9-7.73021541868/1153LPZ(30)/AMPC(750)/CAM(200), BID 7-14DNA
Takenaka et al[88], 2007JapanPrimaryCohortWith/without PU3.17180753.6 ± 12.41289/518Dual therapy or PPI/AMPC(750)/CAM(200 or 400), BID 7D82.9
Ogura et al[89], 2008JapanPrimaryCohortWith/without PU3.270862400/308LPZ(30)/AMPC(750/1000)/CAM(400) or MNZ(250), BID 7D74
Kim et al[90], 2008South KoreaPrimaryCohortWith/without PU9.4179046.71483/297Tripotassi-um dicitrate bismuthate (300, QID)/MNZ(500, TID)/TC(500, QID), 5D or OPZ(20)/CAM(500)/AMPC(1000)BID 7DNA
Mabe et al[53], 2009JapanPrimaryCohortWith/without PU5.6413352.9 (13-91)2964/1169LPZ(30) or OPZ(20)/AMPC(750)/CAM(200 or 400), BID 7D64.8
Yanaoka et al[25], 2009JapanPrimaryCohortNon-gastric cancer9.3412949.85560/107OPZ(20)/AMPC(750 or 500), BID 14D, OPZ(20)/AMPC(750)/CAM(200), BID 7D87.2
Watanabe et al[26], 2012JapanPrimaryCohortNon-gastric cancer5.4823NANAOPZ(20, BID)/AMPC(750 or 500, BID) 14D or OPZ(20)/AMPC(750)/CAM(200), BID 7D82.0
Lee et al[20], 2013ChinaPrimaryCohortWith/without PU or dysplaisa5824249.2 ± 12.81888/2233PPI/AMCP(1000)/CAM(500), BID 7D78.7
Shichijo et al[21], 2015JapanPrimaryCohortIntestinal metaplasia6.7 ± 4.765960.1 ± 11.0374/355LPZ(30)/AMPC(750 or 1000)/CAM(200) or MNZ(250), BID 7DNA
Take et al[91-94]JapanPrimaryCohortPeptic ulcer9.9122249.9 ± 8.31087/135Dual or Triple therapyNA