Validation of the six-and-twelve criteria among patients with hepatocellular carcinoma and performance score 1 receiving transarterial chemoembolization

Table 3 Multivariate analyses for overall survival

Characteristics	Model 1		Model 2		Model 3
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Tumor size, per 1 cm increase	1.10 (1.08-1.12)	< 0.001	1.10 (1.08-1.12)	< 0.001	1.10 (1.07-1.12)	< 0.001
Tumor number, per 1 lesion increase	1.10 (1.07-1.14)	< 0.001	1.10 (1.06-1.64)	< 0.001	1.11 (1.07-1.15)	< 0.001
AFP > 400 ng/mL (Ref: ≤ 400 ng/mL)	1.31 (1.09-1.98)	0.047	1.36 (1.13-1.63)	0.001	1.28 (1.06-1.53)	0.010
Child-Pugh class B (Ref: A)
ALBI grade 2 (Ref: 1)			1.44 (1.20-1.72)	< 0.001
Total bilirubin, per 1 μmol/L increase					1.01 (1.00-1.02)	0.025

Significant characteristics (P < 0.05) in univariate analysis were included in cox regression models, and these variables related to liver function (Child-Pugh grade, ALBI grade and total bilirubin) were respectively included in the multivariate Model 1, Model 2 and Model 3. HR: Hazard ratio; Ref: Reference; AFP: Alpha-fetoprotein; ALBI: Albumin-bilirubin.