Validation of the six-and-twelve criteria among patients with hepatocellular carcinoma and performance score 1 receiving transarterial chemoembolization

Table 2 Univariate analyses for overall survival

Characteristics	HR (95%CI)	P value
Gender, male (Ref: Female)	0.84 (0.66-1.08)	0.167
Age, per yr increase	1.00 (0.99-1.01)	0.429
Etiology Others (Ref: HBV)	0.79 (0.61-1.04)	0.092
Tumor size, per 1 cm increase	1.10 (1.08-1.13)	< 0.001
Tumor number, per 1 lesion increase	1.11 (1.07-1.15)	< 0.001
Child-Pugh class B (Ref: A)	1.41 (1.00-1.98)	0.047
ALBI grade 2 (Ref: 1)	1.35 (1.14-1.61)	0.001
AFP > 400 ng/mL (Ref: ≤ 400 ng/mL)	1.51 (1.26-1.81)	< 0.001
White blood cell, per 1 109/L increase	1.07 (1.04-1.10)	< 0.001
Red blood cell, per 1 106/L increase	0.87 (0.74-1.03)	0.098
Platelets, per 1 109/L increase	1.00 (1.00-1.00)	< 0.001
International normalized ratio, per 1% increase	0.96 (0.46-1.99)	0.903
Alanine aminotransferase, per 1 U/L increase	1.00 (1.00-1.00)	0.606
Aspartate aminotransferase, per 1 U/L increase	1.00 (1.00-1.01)	0.011
Total bilirubin, per 1 μmol/L increase	1.02 (1.01-1.03)	0.004
Albumin, per 1 g/L increase	0.99 (0.98-1.01)	0.200
ALBI score, per 1 score increase	1.18 (0.99-1.40)	0.062
Blood urea nitrogen, per 1 mmol/L increase	0.98 (0.94-1.02)	< 0.315
Creatinine, per 1 μmol/L increase	1.01 (1.00-1.01)	0.881

HR: Hazard ratio; Ref: Reference; HBV: Hepatitis B virus; AFP: Alpha-fetoprotein; ALBI: Albumin-bilirubin.