Blood-based biomarkers for early detection of esophageal squamous cell carcinoma

Table 4 Diagnostic performance of long non-coding RNAs in esophageal squamous cell carcinoma

LncRNA	Ref.	Year of publication	ESCC, n	Controls, n	All stages/early stage			P value	Detection method
					Sensitivity (%)	Specificity (%)	AUC
POU3F3	Hu et al[102]	2016	205	210			0.584/-	< 0.01	qRT-PCR
	Tong et al[103]	2015	147	123	72.8/69.2	89.4/-	0.842/-	< 0.001	qPCR
HOTAIR	Wang et al[104]	2017	50	20	56.0/-	90.0/-	0.793/-	< 0.01	qRT-PCR
HNF1A-AS1	Tong et al[103]	2015	147	123	32.7/-		0.781/-	< 0.001	qPCR
SPRY4-IT1	Tong et al[103]	2015	147	123	48.2/-		0.800/-	< 0.001	qPCR
linc00152	Hu et al[102]	2016	205	210			0.698/-	< 0.01	qRT-PCR
CFLAR-AS1	Hu et al[102]	2016	205	210			0.651/-	< 0.01	qRT-PCR
PGM5-AS1	Zhihua et al[105]	2019	41	26			0.894/-	< 0.001	qRT-PCR

ESCC: Esophageal squamous cell carcinoma; AUC: Area under the curve; lncRNA: Long noncoding RNA; POU3F3: POU class 3 homeobox 3; HOTAIR: HOX transcript antisense RNA; HNF1A‐AS1: Hepatocyte nuclear factor 1 homeobox A antisense RNA 1; SPRY4-IT1: SPRY4 intronic transcript 1; Linc00152: long intergenic non-protein-coding RNA. CFLAR-AS1: CFLAR antisense RNA 1; PGM5-AS1: PGM5 antisense RNA 1.