Blood-based biomarkers for early detection of esophageal squamous cell carcinoma

Table 3 Diagnostic performance of microRNAs in esophageal squamous cell carcinoma

MicroRNA	Ref.	Year of publication	ESCC, n	Controls, n	All stages/early stage			P value	Detection method
					Sensitivity (%)	Specificity (%)	AUC
miR-21	Wang et al[76]	2018	31	32	71.0/-	96.9/-	0.88/-	< 0.001	qRT-PCR
	Sharma et al[77]	2018	24	21	83.3/-	57.2/-	0.692/-	0.027	qRT-PCR
	Zhang et al[78]	2018	125	125	74.0/-	78.0/-	0.80/0.86	< 0.001	RT-qPCR
	Lv et al[79]	2016	126	80			0.796/ 0.812	0.021	qRT-PCR
	Li et al[80]	2015	38	19			0.690/-	0.017	qRT-PCR
	Ye et al[81]	2014	100	50	/97.0	/56.0	/0.837	< 0.001	qRT-PCR
	Kurashige et al[82]	2012	71	39				< 0.001	qRT-PCR
	Wang et al[83]	2012	174	39	71.0/-	69.2/-	0.740/-	< 0.001	qRT-PCR
	Komatsu et al[84]	2011	50	20			0.618/-	0.022	qRT-PCR
miR-223	Zhang et al[78]	2017	125	125	0.68/-	0.68/-	0.73/0.83	< 0.001	RT-qPCR
	Zhou et al[85]	2017	137	155			0.649/-	< 0.001	RT-qPCR
	Wu et al[86]	2014	194	98			0.734/-	0.001	RT-qPCR
	Wu et al[87]	2014	20 (Test)	20 (Validation)			0.90/-	< 0.001	RT-qPCR
			63 (Test)	63 (Validation)			0.77/-	< 0.001	RT-qPCR
	Zhang et al[73]	2010	149	100	83.2/-	83.0/-	0.911/-	< 0.05	RT-qPCR
miR-375	Zhang et al[78]	2017	125	125	0.78/-	0.59/-	0.69/0.87	< 0.001	RT-qPCR
	Lv et al[79]	2016	126	80			0.712/ 0.739	0.023	qRT-PCR
	Li et al[80]	2015	38	19			0.921/-	< 0.0001	qRT-PCR
	Wu et al[86]	2014	194	98			0.720/-	0.007	RT-qPCR
	Komatsu et al[84]	2011	50	20			0.807/-	0.005	qRT-PCR
miR-25	Wang et al[76]	2018	31	32	71.0/-	68.8/-	0.72/-	< 0.001	qRT-PCR
	Zhang et al[78]	2017	125	125	0.54/-	0.57/-	0.55/-	0.025	RT-qPCR
	Wu et al[87]	2014	20 (Test)	20 (Validation)			0.94/-	< 0.001	RT-qPCR
			63 (Test)	63 (Validation)			0.78/-	< 0.001	RT-qPCR
	Wu et al[86]	2014	194	98	47.1/-	71.6/-	0.593/-	0.009	RT-qPCR
	Komatsu et al[88]	2014	20	50	85.0/-	86.0/-	0.856/-	< 0.0001	RT-qPCR
miR-100	Zhang et al[78]	2017	125	125	0.58/-	0.58/-	0.58/0.79	0.164	RT-qPCR
	Wu et al[87]	2014	20 (Test)	20 (Validation)			0.88/-	< 0.001	RT-qPCR
			63 (Test)	63 (Validation)			0.75/-	< 0.001	RT-qPCR
	Zhang et al[73]	2010	149	100	63.8/-	81.0/-	0.817/-	< 0.05	RT-qPCR

ESCC: Esophageal squamous cell carcinoma; AUC: Area under the curve.