Gastrointestinal cancer stem cells as targets for innovative immunotherapy

doi:10.3748/wjg.v26.i14.1580

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 14, 2020; 26(14): 1580-1593
Published online Apr 14, 2020. doi: 10.3748/wjg.v26.i14.1580

Table 3 Targeting gastrointestinal cancer stem cell by natural killer cells, chimeric antigen receptor expressed on T cells and dendritic cells based vaccines

Targeting approach	Cancer model	Ref.
CIK cells via NKG2D ligands expressed on CSC	Hepatocellular carcinoma	[56]
NK cells via NKG2D ligands expressed on CSC	Pancreatic cancer	[57]
CAR-T for CSC antigen ASB4	Colon cancer	[59]
CAR-T for EGFR and CAR-T for CSC antigen CD133	Cholangiocarcinoma	[60]
CAR-T for CSC antigen CD24	Pancreatic adenocarcinoma	[61]
DC loaded with Panc-1 CSC lysate	Pancreatic cancer	[62]
DC loaded with total mRNA from gastric CSC	Gastric cancer	[63]

CIK: Cytokine-induced killer; CSC: Cancer stem cells; NK: Natural killer; CAR-T: Chimeric antigen receptor expressed on T cells; EGFR: Epithelial growth factor; DC: Dendritic cells.

Citation: Chivu-Economescu M, Necula LG, Matei L, Dragu DL, Neagu AI, Alexiu I, Bleotu C, Diaconu CC. Gastrointestinal cancer stem cells as targets for innovative immunotherapy. World J Gastroenterol 2020; 26(14): 1580-1593
URL: https://www.wjgnet.com/1007-9327/full/v26/i14/1580.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i14.1580