Copyright
©The Author(s) 2020.
World J Gastroenterol. Apr 14, 2020; 26(14): 1564-1579
Published online Apr 14, 2020. doi: 10.3748/wjg.v26.i14.1564
Published online Apr 14, 2020. doi: 10.3748/wjg.v26.i14.1564
Metabolic disorder | Morphofunctional changes in intestinal epithelial barrier | Morphofunctional changes in enteric neuromuscular compartment | Ref. |
Human investigations | |||
Obesity | ↑ Circulating LPS | NA | [6] |
↓ Occludin and tri-cellulin immunopositivity | |||
↑ ZO-1 | |||
Diabetes | ↑ Intestinal permeability (urinary excretion of lactulose) | NA | [6] |
Experimental models | |||
HFD-induced obese mice | ↓ ZO-1, occludin and claudins | ↓ Nitrergic and VIPergic neurons Altered smooth muscle cell excitability | [89-91,93,94,96,97] |
↑ Circulating LPS | ↓ Enteric inhibitory neurotransmission | ||
↑ Enteric excitatory tachykininergic neurotransmission | |||
↑ SP immunopositivity | |||
↑ A2B adenosine receptor expression | |||
Lep ob/ob mice | ↑ Intestinal permeability | NA | [92] |
Alterations of villi/crypt length | |||
↓ TJs and mucus-related genes | |||
Ob/ob mice | ↑ Paracellular permeability | ↓ Intestinal motor activity | [95] |
Altered TJs | ↓ ACh receptors | ||
Delayed intestinal transit rate |
- Citation: D’Antongiovanni V, Pellegrini C, Fornai M, Colucci R, Blandizzi C, Antonioli L, Bernardini N. Intestinal epithelial barrier and neuromuscular compartment in health and disease. World J Gastroenterol 2020; 26(14): 1564-1579
- URL: https://www.wjgnet.com/1007-9327/full/v26/i14/1564.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i14.1564