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©The Author(s) 2020.
World J Gastroenterol. Apr 7, 2020; 26(13): 1474-1489
Published online Apr 7, 2020. doi: 10.3748/wjg.v26.i13.1474
Published online Apr 7, 2020. doi: 10.3748/wjg.v26.i13.1474
Figure 3 Effects of long non-coding RNA Opa-interacting protein 5 antisense RNA 1 on colon cancer cell resistance to oxaliplatin.
A: Determined Opa-interacting protein 5 antisense RNA 1 expression in constructed drug-resistant cell lines; B: Effects of oxaliplatin (L-OHP) at different concentrations on growth inhibition of HCT116 and HCT116/L-OHP cells; C: Effects of L-OHP at different concentrations on growth inhibition of SW480 and SW480/L-OHP cells; D: Effects of L-OHP at different concentrations on growth inhibition of HCT116/L-OHP cells in each group after transfection; E: Influence of L-OHP at different concentrations on growth inhibition of SW480/L-OHP cells in each group after transfection; F: Comparison of apoptosis rate of drug-resistant cells among different groups after transfection and apoptosis map; G: Comparison of drug-resistant cell apoptosis among different groups after transfection and apoptotic protein map. SW480/L-OHP indicates SW480 cell line with L-OHP resistance. HCT116/L-OHP indicates HCT116 cell line with L-OHP resistance. aP < 0.05, bP < 0.01, eP < 0.001 for between-group comparisons. OIP5-AS1: Opa-interacting protein 5 antisense RNA 1; L-OHP: Oxaliplatin.
- Citation: Liang J, Tian XF, Yang W. Effects of long non-coding RNA Opa-interacting protein 5 antisense RNA 1 on colon cancer cell resistance to oxaliplatin and its regulation of microRNA-137. World J Gastroenterol 2020; 26(13): 1474-1489
- URL: https://www.wjgnet.com/1007-9327/full/v26/i13/1474.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i13.1474