Preoperative gamma-glutamyltransferase to lymphocyte ratio predicts long-term outcomes in intrahepatic cholangiocarcinoma patients following hepatic resection

doi:10.3748/wjg.v26.i13.1501

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 7, 2020; 26(13): 1501-1512
Published online Apr 7, 2020. doi: 10.3748/wjg.v26.i13.1501

Table 2 Univariate analysis in the derivation cohort

Variables	Overall survival			Recurrence-free survival
Variables	HR	95%CI	P value	HR	95%CI	P value
Age	1.002	0.987-1.017	0.819	0.998	0.985-1.011	0.763
Gender, F/M	0.752	0.546-1.035	0.080^a	0.846	0.633-1.132	0.262
HBsAg	1.210	0.853-1.717	0.285	1.274	0.924-1.756	0.139
Hepatolithiasis	1.593	1.061-2.393	0.025^a	1.176	0.785-1.761	0.433
Child-Pugh grade, A /B	0.614	0.323-1.167	0.136	0.732	0.381-1.367	0.317
Ascites	1.639	1.011-2.658	0.045^a	1.532	0.988-2.376	0.056^a
CA-199 (≥ 22/< 22)	0.953	0.926-0.981	0.001^a	1.546	1.259-1.899	< 0.001^a
Tumor size	1.075	1.012-1.141	0.019^a	1.123	1.063-1.187	< 0.001^a
Tumor number, Multiple/Single	1.655	1.172-2.328	0.004^a	1.893	1.388-2.582	< 0.001^a
Tumor differentiation, Moderate-Poor/Well	1.891	0.699-5.115	0.209	3.277	1.045-10.274	0.042^a
Macrovascular invasion	1.371	0.953-1.972	0.089^a	1.277	0.913-1.787	0.153
Microvascular invasion	1.619	1.029-2.548	0.037^a	1.983	1.306-3.012	0.001^a
Liver capsule invasion	0.815	0.586-1.134	0.225	1.140	0.833-1.561	0.412
Node-positive	2.846	2.030-3.989	< 0.001^a	2.484	1.810-3.409	< 0.001^a
Perineural invasion	1.737	1.129-2.673	0.012^a	1.245	0.821-1.887	0.302
Cirrhosis	1.526	1.094-2.130	0.013^a	1.182	0.863-1.617	0.297
TNM stage, III/I-II	1.067	0.745-1.529	0.722	1.431	1.010-2.028	0.044^a
BCLC, B-C/0-A	1.295	0.906-1.850	0.156	1.607	1.150-2.246	0.005^a
NLR, > 2.62/≤ 2.62	1.701	1.221-2.371	0.002^a	1.422	1.057-1.912	0.020^a
PLR, > 103/≤ 103	1.366	0.983-1.897	0.063^a	1.360	1.009-1.833	0.043^a
GLR, > 33.7/≤ 33.7	2.316	1.617-3.316	< 0.001^a	1.931	1.413-2.639	< 0.001^a

^aP < 0.10. M: male; F: Female; HBV: Hepatitis B virus; CA-199: Carbohydrate antigen-199; TNM: Tumor-node-metastasis; BCLC: Barcelona Clinic Liver Cancer; NLR: Neutrophil to lymphocyte ratio; PLR: Platelet to lymphocyte ratio; GLR: Gamma-glutamyltransferase to lymphocyte ratio; HR: Hazard ratio; CI: Confidence interval.

Citation: Wang JJ, Li H, Li JX, Xu L, Wu H, Zeng Y. Preoperative gamma-glutamyltransferase to lymphocyte ratio predicts long-term outcomes in intrahepatic cholangiocarcinoma patients following hepatic resection. World J Gastroenterol 2020; 26(13): 1501-1512
URL: https://www.wjgnet.com/1007-9327/full/v26/i13/1501.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i13.1501